SPECT-CT Imaging of Dog Spontaneous Diffuse Large B-Cell Lymphoma Targeting CD22 for the Implementation of a Relevant Preclinical Model for Human.
Antibodies directed towards CD22 have been utilized in radioimmunotherapy (RIT) scientific trials to deal with sufferers with diffuse giant B-cell lymphoma (DLBCL) with promising outcomes. However, related preclinical fashions are wanted to facilitate the analysis and optimization of new protocols. Spontaneous DLBCL in canine is a tumor mannequin that will assist speed up the improvement of new methodologies and therapeutic methods for RIT concentrating on CD22.
Seven murine monoclonal antibodies particular for canine CD22 had been produced by the hybridoma technique and characterised. The antibodies‘ affinity and epitopic maps, their internalization functionality and usefulness for prognosis in immunohistochemistry had been decided.
Biodistribution and PET imaging on a mouse xenogeneic mannequin of canine DLBCL was used to decide on the most promising antibody for our functions. PET-CT outcomes confirmed biodistribution examine observations and allowed tumor localization. The chosen antibody, 10C6, was efficiently used on a canine with spontaneous DLBCL for SPECT-CT imaging in the context of illness staging, validating its efficacy for prognosis and the feasibility of future RIT assays.
Nimbolide |
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T16324-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Nimbolide |
Nimbolide |
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T16324-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Nimbolide |
Nimbolide |
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T16324-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Nimbolide |
Nimbolide |
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T16324-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Nimbolide |
Nimbolide |
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T16324-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Nimbolide |
Nimbolide |
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N476300 | Toronto Research Chemicals | 10mg | EUR 328 |
Description: 25990-37-8 |
EZSolution? Nimbolide |
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9655-5 | Biovision | each | EUR 339.6 |
Nimbolidin B |
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TBZ0660 | ChemNorm | unit | Ask for price |
Nimbolidin C |
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TBZ0661 | ChemNorm | unit | Ask for price |
Nimbolidin D |
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TBZ0662 | ChemNorm | unit | Ask for price |
Nimbolidin E |
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TBZ0663 | ChemNorm | unit | Ask for price |
Nimbosone |
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T33675-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Nimbosone |
Nimbosone |
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T33675-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Nimbosone |
Nimbosone |
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T33675-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Nimbosone |
Nimbosone |
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T33675-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Nimbosone |
Nimbosone |
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T33675-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Nimbosone |
Nimbocinone |
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T25873-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Nimbocinone |
Nimbocinone |
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T25873-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Nimbocinone |
Nimbocinone |
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T25873-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Nimbocinone |
Nimbocinone |
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T25873-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Nimbocinone |
Nimbocinone |
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T25873-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Nimbocinone |
Nimbin |
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TN4659-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Nimbin |
Nimbin |
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TN4659-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Nimbin |
Nimbin |
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TN4659-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Nimbin |
Nimbin |
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TN4659-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Nimbin |
Nimbin |
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TN4659-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Nimbin |
Nimbin |
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TB02317 | ChemNorm | 5mg | EUR 885.6 |
Nimbin |
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N476280 | Toronto Research Chemicals | 1mg | EUR 230 |
Description: 5945-86-8 |
Nimbanal |
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N476210 | Toronto Research Chemicals | 1mg | EUR 129 |
Description: 120462-51-3 |
(+)-Nimbidiol |
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N476270 | Toronto Research Chemicals | 25mg | EUR 1800 |
Description: 113332-25-5 |
Nimbidiol |
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T126365-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Nimbidiol |
Nimbidiol |
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T126365-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Nimbidiol |
Nimbidiol |
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T126365-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Nimbidiol |
Nimbidiol |
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T126365-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Nimbidiol |
Nimbidiol |
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T126365-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Nimbidiol |
Nimbinic Acid |
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N476290 | Toronto Research Chemicals | 1mg | EUR 1248 |
Description: 5866-30-8 |
Nimbin acetyl-d3 |
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N476282 | Toronto Research Chemicals | 2.5mg | EUR 1800 |
Desacetyl Nimbin |
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D199000 | Toronto Research Chemicals | 10mg | EUR 409 |
Description: 18609-16-0 |
NIM811 |
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HY-P0025 | MedChemExpress | 10mM/1mL | EUR 4388.4 |
NIM811 |
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T12226-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: NIM811 |
NIM811 |
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T12226-1g | TargetMol Chemicals | 1g | Ask for price |
Description: NIM811 |
NIM811 |
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T12226-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: NIM811 |
NIM811 |
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T12226-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: NIM811 |
NIM811 |
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T12226-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: NIM811 |
NIM1 (untagged)-Human serine/threonine-protein kinase NIM1 (NIM1) |
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SC100346 | Origene Technologies GmbH | 10 µg | Ask for price |
NIM1 (GFP-tagged) - Human serine/threonine-protein kinase NIM1 (NIM1) |
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RG207250 | Origene Technologies GmbH | 10 µg | Ask for price |
NIM1 (Myc-DDK-tagged)-Human serine/threonine-protein kinase NIM1 (NIM1) |
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RC207250 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF particles, NIM1K (Myc-DDK tagged) - Human serine/threonine-protein kinase NIM1 (NIM1), 200ul, >10^7 TU/mL |
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RC207250L1V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF particles, NIM1K (mGFP-tagged) - Human serine/threonine-protein kinase NIM1 (NIM1), 200ul, >10^7 TU/mL |
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RC207250L2V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF particles, NIM1K (Myc-DDK tagged) - Human serine/threonine-protein kinase NIM1 (NIM1), 200ul, >10^7 TU/mL |
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RC207250L3V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF particles, NIM1K (mGFP-tagged) - Human serine/threonine-protein kinase NIM1 (NIM1), 200ul, >10^7 TU/mL |
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RC207250L4V | Origene Technologies GmbH | 200 µl | Ask for price |
NIM-7 |
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T33674-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: NIM-7 |
NIM-7 |
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T33674-1g | TargetMol Chemicals | 1g | Ask for price |
Description: NIM-7 |
NIM-7 |
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T33674-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: NIM-7 |
NIM-7 |
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T33674-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: NIM-7 |
NIM-7 |
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T33674-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: NIM-7 |
Human Serine/threonine-protein kinase NIM1 (NIM1) |
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1-CSB-EP810298HU | Cusabio |
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Description: Recombinant Human Serine/threonine-protein kinase NIM1(NIM1) expressed in E.coli |
Mouse Serine/threonine- protein kinase NIM1, Nim1 ELISA KIT |
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ELI-15091m | Lifescience Market | 96 Tests | EUR 1038 |
Human Serine/threonine- protein kinase NIM1, NIM1 ELISA KIT |
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ELI-16705h | Lifescience Market | 96 Tests | EUR 988.8 |
Serine/threonine-protein kinase NIM1 (NIM1K) Antibody |
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20-abx325405 | Abbexa |
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Serine/threonine-Protein Kinase NIM1 (NIM1K) Antibody |
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20-abx110201 | Abbexa |
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Serine/threonine-Protein Kinase NIM1 (NIM1K) Antibody |
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abx110201-100l | Abbexa | 100 µl | EUR 162.5 |
Serine/threonine-protein kinase NIM1 (NIM1K) Antibody |
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abx325405-100g | Abbexa | 100 µg | EUR 250 |
Serine/threonine-protein kinase NIM1 (NIM1K) Antibody |
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abx325405-50g | Abbexa | 50 µg | EUR 187.5 |
Human Serine/threonine-protein kinase NIM1 (NIM1K) ELISA Kit |
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abx385397-96tests | Abbexa | 96 tests | EUR 1093.2 |
Mouse Serine/threonine-protein kinase NIM1 (NIM1K) ELISA Kit |
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abx390533-96tests | Abbexa | 96 tests | EUR 1093.2 |
Mouse Serine/threonine-protein kinase NIM1 (NIM1K) ELISA Kit |
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abx390533-250g | Abbexa | 250 µg | EUR 687.5 |
Nim1k ELISA Kit| Mouse Serine/threonine-protein kinase NIM1 ELI |
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EF016175 | Lifescience Market | 96 Tests | EUR 826.8 |
Serine/threonine-protein kinase NIM1 (NIM1K) Antibody (FITC) |
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20-abx337636 | Abbexa |
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Serine/threonine-protein kinase NIM1 (NIM1K) Antibody (FITC) |
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abx337636-100l | Abbexa | 100 µl | EUR 250 |
Serine/threonine-protein kinase NIM1 (NIM1K) Antibody (FITC) |
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abx337636-50l | Abbexa | 50 µl | EUR 162.5 |
NIM1K siRNA |
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20-abx925905 | Abbexa |
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NIM1K siRNA |
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20-abx925906 | Abbexa |
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Recombinant Human Serine/threonine-protein kinase NIM1 (NIM1) |
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CSB-EP810298HU | Cusabio | 4193 mg | Ask for price |
Recombinant Human Serine/threonine-protein kinase NIM1(NIM1) |
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AP71391 | SAB | 1mg | EUR 1978 |
NIM1 Antibody |
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E19-4468 | EnoGene | 100μg/100μl | EUR 225 |
Description: Available in various conjugation types. |
NIM1 Antibody |
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E11-18586C | EnoGene | 100μg | EUR 225 |
Description: Available in various conjugation types. |
NIM1 Antibody |
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DF4468 | Affbiotech | 200ul | EUR 420 |
NIM1 Antibody |
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DF4468-100ul | Affinity Biosciences | 100ul | EUR 280 |
NIM1 Antibody |
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DF4468-200ul | Affinity Biosciences | 200ul | EUR 350 |
NIM1 Antibody |
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ABD4468 | Lifescience Market | 100 ug | EUR 525.6 |
NIM1 Antibody |
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abx218509-100ug | Abbexa | 100 ug | EUR 526.8 |
Lenti ORF clone of Human serine/threonine-protein kinase NIM1 (NIM1), mGFP tagged |
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RC207250L2 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF clone of Human serine/threonine-protein kinase NIM1 (NIM1), mGFP tagged |
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RC207250L4 | Origene Technologies GmbH | 10 µg | Ask for price |
NIM1K Antibody |
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1-CSB-PA007750 | Cusabio |
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Description: A polyclonal antibody against NIM1K. Recognizes NIM1K from Human, Mouse. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/10000 |
NIM1K Antibody |
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1-CSB-PA810298LA01HU | Cusabio |
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Description: A polyclonal antibody against NIM1K. Recognizes NIM1K from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200 |
NIM1K ELISA KIT|Human |
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EF005554 | Lifescience Market | 96 Tests | EUR 826.8 |
Lenti ORF clone of Human serine/threonine-protein kinase NIM1 (NIM1), Myc-DDK-tagged |
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RC207250L1 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF clone of Human serine/threonine-protein kinase NIM1 (NIM1), Myc-DDK-tagged |
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RC207250L3 | Origene Technologies GmbH | 10 µg | Ask for price |
Mouse Nim1 Antibody |
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abx027691-400ul | Abbexa | 400 ul | EUR 627.6 |
Mouse Nim1 Antibody |
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abx027691-80l | Abbexa | 80 µl | EUR 343.2 |
Mouse Nim1 Antibody |
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abx027691-400l | Abbexa | 400 µl | EUR 518.75 |
NIM1 Blocking Peptide |
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DF4468-BP | Affbiotech | 1mg | EUR 234 |
Nim1 (C-term) (Mouse) Rabbit pAb |
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E2612518 | EnoGene | 100ul | EUR 225 |
Description: Available in various conjugation types. |
Mouse NIM1K shRNA Plasmid |
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20-abx982744 | Abbexa |
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Human NIM1K shRNA Plasmid |
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20-abx966056 | Abbexa |
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NIM1 (untagged)-Kinase deficient mutant (K103M) of Human serine/threonine-protein kinase NIM1 (MGC42105) |
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SC323705 | Origene Technologies GmbH | 10 µg | Ask for price |
NIM1 Polyclonal Antibody |
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E20-73128 | EnoGene | 100ug | EUR 225 |
Description: Available in various conjugation types. |
NIM1 Polyclonal Antibody |
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ABP53992-003ml | Abbkine | 0.03ml | EUR 189.6 |
Description: A polyclonal antibody for detection of NIM1 from Human, Mouse. This NIM1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human NIM1 at AA rangle: 320-400 |
NIM1 Polyclonal Antibody |
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ABP53992-01ml | Abbkine | 0.1ml | EUR 346.8 |
Description: A polyclonal antibody for detection of NIM1 from Human, Mouse. This NIM1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human NIM1 at AA rangle: 320-400 |
NIM1 Polyclonal Antibody |
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ABP53992-02ml | Abbkine | 0.2ml | EUR 496.8 |
Description: A polyclonal antibody for detection of NIM1 from Human, Mouse. This NIM1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human NIM1 at AA rangle: 320-400 |
Human NIM1K knockout cell line |
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ABC-KH10103 | AcceGen | 1 vial | Ask for price |
Description: Human NIM1K knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology. |
NIM1 Polyclonal Antibody |
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E44H05481 | EnoGene | 100ul | EUR 255 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
NIM1K Polyclonal Antibody |
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A54360 | EpiGentek |
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Human NIM1K knockdown cell line |
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ABC-KD10103 | AcceGen | 1 vial | Ask for price |
Description: Human NIM1K knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest. |
Human NIM1K Protein Lysate 20ug |
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IHUNIM1KPLLY20UG | Innovative research | each | EUR 213 |
Description: Human NIM1K Protein Lysate 20ug |
Recombinant Human NIM1 (N-GST tag) |
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Z500258 | ABM | 10 µg | EUR 370 |
Description: NIM1 belongs to CAMK Ser/Thr protein kinase family. Unlike to other AMPK-related kinases, NIM1 cannot be phosphorylated and activated by LKB1 . Two somatic mutations (P333S and P411T) were found in lung neuroendocrine carcinoma and lung large cell carcinoma samples . |
NIM1K Antibody, HRP conjugated |
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1-CSB-PA810298LB01HU | Cusabio |
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Description: A polyclonal antibody against NIM1K. Recognizes NIM1K from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
NIM1K Antibody, FITC conjugated |
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1-CSB-PA810298LC01HU | Cusabio |
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Description: A polyclonal antibody against NIM1K. Recognizes NIM1K from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
NIM1 Rabbit Polyclonal Antibody |
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ES4991-100ul | ELK Biotech | 100ul | EUR 124 |
Description: A Rabbit Polyclonal antibody against NIM1 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA |
NIM1 Rabbit Polyclonal Antibody |
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ES4991-50ul | ELK Biotech | 50ul | EUR 74 |
Description: A Rabbit Polyclonal antibody against NIM1 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA |
OACA05279-50UG - NIM1K Antibody |
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OACA05279-50UG | Aviva Systems Biology | 50ug | EUR 179 |
NIM1K Antibody, Biotin conjugated |
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1-CSB-PA810298LD01HU | Cusabio |
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Description: A polyclonal antibody against NIM1K. Recognizes NIM1K from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
OACA05279-100UG - NIM1K Antibody |
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OACA05279-100UG | Aviva Systems Biology | 100ug | EUR 319 |
Polyclonal Mouse Nim1 Antibody (C-term) |
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APR17437G | Leading Biology | 0.1ml | EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Mouse Nim1 (C-term). This antibody is tested and proven to work in the following applications: |
OCOA05437-20UG - NIM1K Protein Lysate |
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OCOA05437-20UG | Aviva Systems Biology | 20ug | EUR 169 |
Mouse Nim1 Rabbit Polyclonal Antibody |
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E10G31363 | EnoGene | 100 μl | EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
h NIM1 inducible lentiviral particles |
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LVP201 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made tet-inducible lentiviral particles expressing a human gene with a Blasticidin-RFP fusion marker (Dual selection). The expressed human gene, NIM1, is fully sequence verified and matched to NCBI accession ID: NM_153361 |
NIM1K Polyclonal Antibody, HRP Conjugated |
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A54359 | EpiGentek |
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AAP53174-100UG - NIM1 Peptide - middle region |
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AAP53174-100UG | Aviva Systems Biology | 100ug | EUR 99 |
This first try at phenotypic imaging on canine paves the solution to implementing quantitative imaging methodologies that might be transposable to people in a theranostic strategy. Taking under consideration the suggestions of present human radioimmunotherapy scientific trials concentrating on CD22, animal trials are deliberate to analyze protocol enhancements which can be troublesome to think about in people as a result of moral considerations.