SPECT-CT Imaging of Dog Spontaneous Diffuse Large B-Cell Lymphoma Targeting CD22 for the Implementation of a Relevant Preclinical Model for Human.
Antibodies directed towards CD22 have been utilized in radioimmunotherapy (RIT) scientific trials to deal with sufferers with diffuse giant B-cell lymphoma (DLBCL) with promising outcomes. However, related preclinical fashions are wanted to facilitate the analysis and optimization of new protocols. Spontaneous DLBCL in canine is a tumor mannequin that will assist speed up the improvement of new methodologies and therapeutic methods for RIT concentrating on CD22.
Seven murine monoclonal antibodies particular for canine CD22 had been produced by the hybridoma technique and characterised. The antibodies‘ affinity and epitopic maps, their internalization functionality and usefulness for prognosis in immunohistochemistry had been decided.
Biodistribution and PET imaging on a mouse xenogeneic mannequin of canine DLBCL was used to decide on the most promising antibody for our functions. PET-CT outcomes confirmed biodistribution examine observations and allowed tumor localization. The chosen antibody, 10C6, was efficiently used on a canine with spontaneous DLBCL for SPECT-CT imaging in the context of illness staging, validating its efficacy for prognosis and the feasibility of future RIT assays.

Nimbolidin B |
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TBZ0660 | ChemNorm | unit | Ask for price |
Nimbolidin C |
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TBZ0661 | ChemNorm | unit | Ask for price |
Nimbolidin D |
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TBZ0662 | ChemNorm | unit | Ask for price |
Nimbolidin E |
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TBZ0663 | ChemNorm | unit | Ask for price |
Nimbin |
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TB02317 | ChemNorm | 5mg | EUR 885.6 |
NIM811 |
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HY-P0025 | MedChemExpress | 10mM/1mL | EUR 4388.4 |
Human Serine/threonine-protein kinase NIM1 (NIM1) |
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1-CSB-EP810298HU | Cusabio |
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Description: Recombinant Human Serine/threonine-protein kinase NIM1(NIM1) expressed in E.coli |
Mouse Serine/threonine- protein kinase NIM1, Nim1 ELISA KIT |
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ELI-15091m | Lifescience Market | 96 Tests | EUR 1038 |
Human Serine/threonine- protein kinase NIM1, NIM1 ELISA KIT |
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ELI-16705h | Lifescience Market | 96 Tests | EUR 988.8 |
Serine/threonine-Protein Kinase NIM1 (NIM1K) Antibody |
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20-abx110201 | Abbexa |
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Serine/threonine-protein kinase NIM1 (NIM1K) Antibody |
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20-abx325405 | Abbexa |
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Mouse Serine/threonine-protein kinase NIM1 (NIM1K) ELISA Kit |
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abx390533-96tests | Abbexa | 96 tests | EUR 1093.2 |
Human Serine/threonine-protein kinase NIM1 (NIM1K) ELISA Kit |
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abx385397-96tests | Abbexa | 96 tests | EUR 1093.2 |
NIM1K siRNA |
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20-abx925905 | Abbexa |
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NIM1K siRNA |
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20-abx925906 | Abbexa |
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Serine/threonine-protein kinase NIM1 (NIM1K) Antibody (FITC) |
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20-abx337636 | Abbexa |
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Nim1k ELISA Kit| Mouse Serine/threonine-protein kinase NIM1 ELI |
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EF016175 | Lifescience Market | 96 Tests | EUR 826.8 |
NIM1 Antibody |
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abx218509-100ug | Abbexa | 100 ug | EUR 526.8 |
NIM1 Antibody |
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ABD4468 | Lifescience Market | 100 ug | EUR 525.6 |
NIM1 Antibody |
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DF4468 | Affbiotech | 200ul | EUR 420 |
NIM1K Antibody |
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1-CSB-PA810298LA01HU | Cusabio |
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Description: A polyclonal antibody against NIM1K. Recognizes NIM1K from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200 |
NIM1K Antibody |
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1-CSB-PA007750 | Cusabio |
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Description: A polyclonal antibody against NIM1K. Recognizes NIM1K from Human, Mouse. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/10000 |
NIM1K ELISA KIT|Human |
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EF005554 | Lifescience Market | 96 Tests | EUR 826.8 |
Mouse Nim1 Antibody |
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abx027691-400ul | Abbexa | 400 ul | EUR 627.6 |
Mouse Nim1 Antibody |
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abx027691-80l | Abbexa | 80 µl | EUR 343.2 |
NIM1 Blocking Peptide |
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DF4468-BP | Affbiotech | 1mg | EUR 234 |
Human NIM1K shRNA Plasmid |
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20-abx966056 | Abbexa |
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Mouse NIM1K shRNA Plasmid |
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20-abx982744 | Abbexa |
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NIM1 Polyclonal Antibody |
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ABP53992-003ml | Abbkine | 0.03ml | EUR 189.6 |
Description: A polyclonal antibody for detection of NIM1 from Human, Mouse. This NIM1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human NIM1 at AA rangle: 320-400 |
NIM1 Polyclonal Antibody |
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ABP53992-01ml | Abbkine | 0.1ml | EUR 346.8 |
Description: A polyclonal antibody for detection of NIM1 from Human, Mouse. This NIM1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human NIM1 at AA rangle: 320-400 |
NIM1 Polyclonal Antibody |
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ABP53992-02ml | Abbkine | 0.2ml | EUR 496.8 |
Description: A polyclonal antibody for detection of NIM1 from Human, Mouse. This NIM1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human NIM1 at AA rangle: 320-400 |
NIM1 Polyclonal Antibody |
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ES4991-100ul | ELK Biotech | 100ul | EUR 334.8 |
Description: A Rabbit Polyclonal antibody against NIM1 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA |
NIM1 Polyclonal Antibody |
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ES4991-50ul | ELK Biotech | 50ul | EUR 248.4 |
Description: A Rabbit Polyclonal antibody against NIM1 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA |
NIM1K Polyclonal Antibody |
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A54360 | EpiGentek |
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NIM1K Antibody, HRP conjugated |
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1-CSB-PA810298LB01HU | Cusabio |
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Description: A polyclonal antibody against NIM1K. Recognizes NIM1K from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
NIM1K Antibody, FITC conjugated |
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1-CSB-PA810298LC01HU | Cusabio |
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Description: A polyclonal antibody against NIM1K. Recognizes NIM1K from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
NIM1K Antibody, Biotin conjugated |
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1-CSB-PA810298LD01HU | Cusabio |
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Description: A polyclonal antibody against NIM1K. Recognizes NIM1K from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
Polyclonal Mouse Nim1 Antibody (C-term) |
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APR17437G | Leading Biology | 0.1ml | EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Mouse Nim1 (C-term). This antibody is tested and proven to work in the following applications: |
h NIM1 inducible lentiviral particles |
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LVP201 | GenTarget | 1x107 IFU/ml x 200ul | EUR 541.2 |
Description: Pre-made tet-inducible lentiviral particles expressing a human gene with a Blasticidin-RFP fusion marker (Dual selection). The expressed human gene, NIM1, is fully sequence verified and matched to NCBI accession ID: NM_153361 |
NIM1K Polyclonal Antibody, HRP Conjugated |
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A54359 | EpiGentek |
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NIM1K Polyclonal Antibody, FITC Conjugated |
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A54358 | EpiGentek |
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anti-Serine/threonine-protein kinase NIM1 |
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YF-PA22606 | Abfrontier | 50 ug | EUR 435.6 |
Description: Mouse polyclonal to Serine/threonine-protein kinase NIM1 |
anti-Serine/threonine-protein kinase NIM1 |
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YF-PA26944 | Abfrontier | 50 ul | EUR 400.8 |
Description: Mouse polyclonal to Serine/threonine-protein kinase NIM1 |
NIM1K Polyclonal Antibody, Biotin Conjugated |
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A54357 | EpiGentek |
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Serine / threonine-protein kinase NIM1 Antibody (HRP) |
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20-abx108746 | Abbexa |
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Serine / threonine-protein kinase NIM1 Antibody (Biotin) |
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20-abx105910 | Abbexa |
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Nimorazole |
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B3510-10 | ApexBio | 10 mg | EUR 160.8 |
Nimorazole |
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B3510-100 | ApexBio | 100 mg | EUR 259.2 |
Nimorazole |
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B3510-200 | ApexBio | 200 mg | EUR 339.6 |
Nimorazole |
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B3510-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 180 |
Nimorazole |
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B3510-50 | ApexBio | 50 mg | EUR 200.4 |
Nimorazole |
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B3510-500 | ApexBio | 500 mg | EUR 621.6 |
Nimesulide |
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B1452-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 129.6 |
Description: Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties.Nimesulide is a selective COX-2 inhibitor used in a variety of inflammatory, pain and fever states. After healthy volunteers |
Nimesulide |
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B1452-50 | ApexBio | 50 mg | EUR 153.6 |
Description: Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties.Nimesulide is a selective COX-2 inhibitor used in a variety of inflammatory, pain and fever states. After healthy volunteers |
Nimesulide |
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B1452-S | ApexBio | Evaluation Sample | EUR 97.2 |
Description: Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties.Nimesulide is a selective COX-2 inhibitor used in a variety of inflammatory, pain and fever states. After healthy volunteers |
Nimesulide |
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2777-1G | Biovision | each | EUR 157.2 |
Nimesulide |
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2777-5G | Biovision | each | EUR 301.2 |
Nimorazole |
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9521-250 | Biovision | each | EUR 314.4 |
Nimorazole |
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9521-50 | Biovision | each | EUR 157.2 |
Nimodipine |
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A8484-100 | ApexBio | 100 mg | EUR 129.6 |
Description: Nimodipine is an L-type calcium channel protein inhibitor. Nimodipine is an inhibitor of Mdr. |
Nimodipine |
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A8484-1000 | ApexBio | 1 g | EUR 268.8 |
Description: Nimodipine is an L-type calcium channel protein inhibitor. Nimodipine is an inhibitor of Mdr. |
Nimodipine |
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A8484-5.1 | ApexBio | 10 mM (in 1mL Ethanol) | EUR 135.6 |
Description: Nimodipine is an L-type calcium channel protein inhibitor. Nimodipine is an inhibitor of Mdr. |
Nimorazole |
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HY-16349 | MedChemExpress | 10mM/1mL | EUR 151.2 |
Nimodipine |
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HY-B0265 | MedChemExpress | 500mg | EUR 176.4 |
Nimesulide |
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HY-B0363 | MedChemExpress | 10mM/1mL | EUR 151.2 |
Nimodipine |
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GP2955-100MG | Glentham Life Sciences | 100 mg | EUR 88.8 |
Nimodipine |
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GP2955-100 | Glentham Life Sciences | 100 | EUR 43.5 |
Recombinant Human Serine/ threonine-protein kinase NIM1 Protein, His-SUMO, E.coli-1mg |
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QP7811-ec-1mg | EnQuireBio | 1mg | EUR 1958.4 |
Recombinant Human Serine/ threonine-protein kinase NIM1 Protein, His-SUMO, E.coli-100ug |
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QP7811-ec-100ug | EnQuireBio | 100ug | EUR 489.6 |
Recombinant Human Serine/ threonine-protein kinase NIM1 Protein, His-SUMO, E.coli-10ug |
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QP7811-ec-10ug | EnQuireBio | 10ug | EUR 240 |
Recombinant Human Serine/ threonine-protein kinase NIM1 Protein, His-SUMO, E.coli-200ug |
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QP7811-ec-200ug | EnQuireBio | 200ug | EUR 760.8 |
Recombinant Human Serine/ threonine-protein kinase NIM1 Protein, His-SUMO, E.coli-500ug |
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QP7811-ec-500ug | EnQuireBio | 500ug | EUR 1272 |
Recombinant Human Serine/ threonine-protein kinase NIM1 Protein, His-SUMO, E.coli-50ug |
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QP7811-ec-50ug | EnQuireBio | 50ug | EUR 315.6 |
NIMA Related Kinase 9 (NEK9) ELISA Kit |
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abx595418-96tests | Abbexa | 96 tests | EUR 764.4 |
Spare NiMH Battery Pack for PIP9390 |
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PIP9392 | Scientific Laboratory Supplies | EACH | EUR 90 |
Nimustine (hydrochloride) |
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HY-13703A | MedChemExpress | 100mg | EUR 680.4 |
Nimustine hydrochloride |
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GP5132-1 | Glentham Life Sciences | 1 | EUR 110.8 |
NIMA Related Kinase 3 (NEK3) Antibody |
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abx235653-100ug | Abbexa | 100 ug | EUR 577.2 |
NIMA Related Kinase 9 (NEK9) Antibody |
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abx235654-100ug | Abbexa | 100 ug | EUR 577.2 |
NIMA Related Kinase 1 (NEK1) Antibody |
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20-abx212767 | Abbexa |
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NIMA Related Kinase 4 (NEK4) Antibody |
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20-abx212768 | Abbexa |
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NIMA Related Kinase 4 (NEK4) Antibody |
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20-abx212769 | Abbexa |
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NIMA Related Kinase 9 (NEK9) Antibody |
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20-abx212770 | Abbexa |
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NIMA Related Kinase 8 (NEK8) Antibody |
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20-abx214457 | Abbexa |
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NIMA Related Kinase 8 (NEK8) Antibody |
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20-abx214596 | Abbexa |
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NIMA Related Kinase 5 (NEK5) Antibody |
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20-abx210683 | Abbexa |
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NIMA Related Kinase 7 (NEK7) Antibody |
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20-abx141139 | Abbexa |
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NIMA Related Kinase 3 (NEK3) Antibody |
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20-abx141364 | Abbexa |
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NIMA Related Kinase 8 (NEK8) Antibody |
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abx117018-100ug | Abbexa | 100 ug | EUR 560.4 |
NIMA Related Kinase 5 (NEK5) Antibody |
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20-abx325664 | Abbexa |
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NIMA Related Kinase 7 (NEK7) Antibody |
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20-abx325962 | Abbexa |
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NIMA Related Kinase 3 (NEK3) Antibody |
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20-abx321804 | Abbexa |
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NIMA Related Kinase 4 (NEK4) Antibody |
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20-abx333749 | Abbexa |
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NIMA Related Kinase 7 (NEK7) Antibody |
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20-abx333801 | Abbexa |
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NIMA Related Kinase 5 (NEK5) Antibody |
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20-abx333931 | Abbexa |
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NIMA Related Kinase 5 (NEK5) Antibody |
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abx330693-100ul | Abbexa | 100 ul | EUR 510 |
NIMA Related Kinase 4 (NEK4) Antibody |
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20-abx326454 | Abbexa |
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NIMA Related Kinase 3 (NEK3) Antibody |
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abx033853-400ul | Abbexa | 400 ul | EUR 627.6 |
NIMA Related Kinase 3 (NEK3) Antibody |
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abx033853-80l | Abbexa | 80 µl | EUR 343.2 |
NIMA Related Kinase 4 (NEK4) Antibody |
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abx033854-400ul | Abbexa | 400 ul | EUR 627.6 |
NIMA Related Kinase 4 (NEK4) Antibody |
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abx033854-80l | Abbexa | 80 µl | EUR 343.2 |
NIMA Related Kinase 7 (NEK7) Antibody |
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abx033856-400ul | Abbexa | 400 ul | EUR 627.6 |
NIMA Related Kinase 7 (NEK7) Antibody |
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abx033856-80l | Abbexa | 80 µl | EUR 343.2 |
NIMA Related Kinase 9 (NEK9) Antibody |
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abx033857-400ul | Abbexa | 400 ul | EUR 627.6 |
NIMA Related Kinase 9 (NEK9) Antibody |
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abx033857-80l | Abbexa | 80 µl | EUR 343.2 |
NIMA Related Kinase 8 (NEK8) Antibody |
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abx033172-400ul | Abbexa | 400 ul | EUR 627.6 |
NIMA Related Kinase 8 (NEK8) Antibody |
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abx033172-80l | Abbexa | 80 µl | EUR 343.2 |
NIMA Related Kinase 8 (NEK8) Antibody |
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abx122674-100ug | Abbexa | 100 ug | EUR 469.2 |
NIMA Related Kinase 9 (NEK9) Antibody |
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20-abx328090 | Abbexa |
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NIMA Related Kinase 1 (NEK1) Antibody |
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20-abx334225 | Abbexa |
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NIMA Related Kinase 9 (NEK9) Antibody |
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20-abx338863 | Abbexa |
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NIMA Related Kinase 8 (NEK8) Antibody |
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20-abx321017 | Abbexa |
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NIMA Related Kinase 8 (NEK8) Antibody |
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20-abx321018 | Abbexa |
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NIMA Related Kinase 5 (NEK5) Antibody |
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20-abx339915 | Abbexa |
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NIMA Related Kinase 7 (NEK7) Antibody |
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abx432045-200ul | Abbexa | 200 ul | EUR 460.8 |
NIMA Related Kinase 7 (NEK7) Antibody |
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abx432046-200ul | Abbexa | 200 ul | EUR 460.8 |
NIMA Related Kinase 8 (NEK8) Antibody |
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20-abx000937 | Abbexa |
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NIMA Related Kinase 3 (NEK3) Antibody |
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20-abx005111 | Abbexa |
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NIMA Related Kinase 5 (NEK5) Antibody |
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20-abx014856 | Abbexa |
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NIMA Related Kinase 11 (NEK11) Antibody |
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abx235650-100ug | Abbexa | 100 ug | EUR 577.2 |
This first try at phenotypic imaging on canine paves the solution to implementing quantitative imaging methodologies that might be transposable to people in a theranostic strategy. Taking under consideration the suggestions of present human radioimmunotherapy scientific trials concentrating on CD22, animal trials are deliberate to analyze protocol enhancements which can be troublesome to think about in people as a result of moral considerations.