SPECT-CT Imaging of Dog Spontaneous Diffuse Large B-Cell Lymphoma Targeting CD22 for the Implementation of a Relevant Preclinical Model for Human.

Antibodies directed towards CD22 have been utilized in radioimmunotherapy (RIT) scientific trials to deal with sufferers with diffuse giant B-cell lymphoma (DLBCL) with promising outcomes. However, related preclinical fashions are wanted to facilitate the analysis and optimization of new protocols. Spontaneous DLBCL in canine is a tumor mannequin that will assist speed up the improvement of new methodologies and therapeutic methods for RIT concentrating on CD22.

Seven murine monoclonal antibodies particular for canine CD22 had been produced by the hybridoma technique and characterised. The antibodies‘ affinity and epitopic maps, their internalization functionality and usefulness for prognosis in immunohistochemistry had been decided.

Biodistribution and PET imaging on a mouse xenogeneic mannequin of canine DLBCL was used to decide on the most promising antibody for our functions. PET-CT outcomes confirmed biodistribution examine observations and allowed tumor localization. The chosen antibody, 10C6, was efficiently used on a canine with spontaneous DLBCL for SPECT-CT imaging in the context of illness staging, validating its efficacy for prognosis and the feasibility of future RIT assays.

SPECT-CT Imaging of Dog Spontaneous Diffuse Large B-Cell Lymphoma Targeting CD22 for the Implementation of a Relevant Preclinical Model for Human.
SPECT-CT Imaging of Dog Spontaneous Diffuse Large B-Cell Lymphoma Targeting CD22 for the Implementation of a Relevant Preclinical Model for Human.

Nimbolidin B

TBZ0660 unit Ask for price

Nimbolidin C

TBZ0661 unit Ask for price

Nimbolidin D

TBZ0662 unit Ask for price

Nimbolidin E

TBZ0663 unit Ask for price

Nimbin

TB02317 5mg
EUR 885.6

NIM811

HY-P0025 10mM/1mL
EUR 4388.4

Human Serine/threonine-protein kinase NIM1 (NIM1)

1-CSB-EP810298HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Serine/threonine-protein kinase NIM1(NIM1) expressed in E.coli

Mouse Serine/threonine- protein kinase NIM1, Nim1 ELISA KIT

ELI-15091m 96 Tests
EUR 1038

Human Serine/threonine- protein kinase NIM1, NIM1 ELISA KIT

ELI-16705h 96 Tests
EUR 988.8

Serine/threonine-Protein Kinase NIM1 (NIM1K) Antibody

20-abx110201
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Serine/threonine-protein kinase NIM1 (NIM1K) Antibody

20-abx325405
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Mouse Serine/threonine-protein kinase NIM1 (NIM1K) ELISA Kit

abx390533-96tests 96 tests
EUR 1093.2

Human Serine/threonine-protein kinase NIM1 (NIM1K) ELISA Kit

abx385397-96tests 96 tests
EUR 1093.2

NIM1K siRNA

20-abx925905
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

NIM1K siRNA

20-abx925906
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

Serine/threonine-protein kinase NIM1 (NIM1K) Antibody (FITC)

20-abx337636
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Nim1k ELISA Kit| Mouse Serine/threonine-protein kinase NIM1 ELI

EF016175 96 Tests
EUR 826.8

NIM1 Antibody

abx218509-100ug 100 ug
EUR 526.8

NIM1 Antibody

ABD4468 100 ug
EUR 525.6

NIM1 Antibody

DF4468 200ul
EUR 420

NIM1K Antibody

1-CSB-PA810298LA01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against NIM1K. Recognizes NIM1K from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

NIM1K Antibody

1-CSB-PA007750
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against NIM1K. Recognizes NIM1K from Human, Mouse. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/10000

NIM1K ELISA KIT|Human

EF005554 96 Tests
EUR 826.8

Mouse Nim1 Antibody

abx027691-400ul 400 ul
EUR 627.6

Mouse Nim1 Antibody

abx027691-80l 80 µl
EUR 343.2

NIM1 Blocking Peptide

DF4468-BP 1mg
EUR 234

Human NIM1K shRNA Plasmid

20-abx966056
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Mouse NIM1K shRNA Plasmid

20-abx982744
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

NIM1 Polyclonal Antibody

ABP53992-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of NIM1 from Human, Mouse. This NIM1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human NIM1 at AA rangle: 320-400

NIM1 Polyclonal Antibody

ABP53992-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of NIM1 from Human, Mouse. This NIM1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human NIM1 at AA rangle: 320-400

NIM1 Polyclonal Antibody

ABP53992-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of NIM1 from Human, Mouse. This NIM1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human NIM1 at AA rangle: 320-400

NIM1 Polyclonal Antibody

ES4991-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against NIM1 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

NIM1 Polyclonal Antibody

ES4991-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against NIM1 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

NIM1K Polyclonal Antibody

A54360
  • EUR 684.66
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  • Ask for price
  • EUR 423.50
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

NIM1K Antibody, HRP conjugated

1-CSB-PA810298LB01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against NIM1K. Recognizes NIM1K from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

NIM1K Antibody, FITC conjugated

1-CSB-PA810298LC01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against NIM1K. Recognizes NIM1K from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

NIM1K Antibody, Biotin conjugated

1-CSB-PA810298LD01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against NIM1K. Recognizes NIM1K from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Polyclonal Mouse Nim1 Antibody (C-term)

APR17437G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Mouse Nim1 (C-term). This antibody is tested and proven to work in the following applications:

h NIM1 inducible lentiviral particles

LVP201 1x107 IFU/ml x 200ul
EUR 541.2
Description: Pre-made tet-inducible lentiviral particles expressing a human gene with a Blasticidin-RFP fusion marker (Dual selection). The expressed human gene, NIM1, is fully sequence verified and matched to NCBI accession ID: NM_153361

NIM1K Polyclonal Antibody, HRP Conjugated

A54359
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

NIM1K Polyclonal Antibody, FITC Conjugated

A54358
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

anti-Serine/threonine-protein kinase NIM1

YF-PA22606 50 ug
EUR 435.6
Description: Mouse polyclonal to Serine/threonine-protein kinase NIM1

anti-Serine/threonine-protein kinase NIM1

YF-PA26944 50 ul
EUR 400.8
Description: Mouse polyclonal to Serine/threonine-protein kinase NIM1

NIM1K Polyclonal Antibody, Biotin Conjugated

A54357
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

Serine / threonine-protein kinase NIM1 Antibody (HRP)

20-abx108746
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Serine / threonine-protein kinase NIM1 Antibody (Biotin)

20-abx105910
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Nimorazole

B3510-10 10 mg
EUR 160.8

Nimorazole

B3510-100 100 mg
EUR 259.2

Nimorazole

B3510-200 200 mg
EUR 339.6

Nimorazole

B3510-5.1 10 mM (in 1mL DMSO)
EUR 180

Nimorazole

B3510-50 50 mg
EUR 200.4

Nimorazole

B3510-500 500 mg
EUR 621.6

Nimesulide

B1452-5.1 10 mM (in 1mL DMSO)
EUR 129.6
Description: Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties.Nimesulide is a selective COX-2 inhibitor used in a variety of inflammatory, pain and fever states. After healthy volunteers

Nimesulide

B1452-50 50 mg
EUR 153.6
Description: Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties.Nimesulide is a selective COX-2 inhibitor used in a variety of inflammatory, pain and fever states. After healthy volunteers

Nimesulide

B1452-S Evaluation Sample
EUR 97.2
Description: Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties.Nimesulide is a selective COX-2 inhibitor used in a variety of inflammatory, pain and fever states. After healthy volunteers

Nimesulide

2777-1G each
EUR 157.2

Nimesulide

2777-5G each
EUR 301.2

Nimorazole

9521-250 each
EUR 314.4

Nimorazole

9521-50 each
EUR 157.2

Nimodipine

A8484-100 100 mg
EUR 129.6
Description: Nimodipine is an L-type calcium channel protein inhibitor. Nimodipine is an inhibitor of Mdr.

Nimodipine

A8484-1000 1 g
EUR 268.8
Description: Nimodipine is an L-type calcium channel protein inhibitor. Nimodipine is an inhibitor of Mdr.

Nimodipine

A8484-5.1 10 mM (in 1mL Ethanol)
EUR 135.6
Description: Nimodipine is an L-type calcium channel protein inhibitor. Nimodipine is an inhibitor of Mdr.

Nimorazole

HY-16349 10mM/1mL
EUR 151.2

Nimodipine

HY-B0265 500mg
EUR 176.4

Nimesulide

HY-B0363 10mM/1mL
EUR 151.2

Nimodipine

GP2955-100MG 100 mg
EUR 88.8

Nimodipine

GP2955-100 100
EUR 43.5

Recombinant Human Serine/ threonine-protein kinase NIM1 Protein, His-SUMO, E.coli-1mg

QP7811-ec-1mg 1mg
EUR 1958.4

Recombinant Human Serine/ threonine-protein kinase NIM1 Protein, His-SUMO, E.coli-100ug

QP7811-ec-100ug 100ug
EUR 489.6

Recombinant Human Serine/ threonine-protein kinase NIM1 Protein, His-SUMO, E.coli-10ug

QP7811-ec-10ug 10ug
EUR 240

Recombinant Human Serine/ threonine-protein kinase NIM1 Protein, His-SUMO, E.coli-200ug

QP7811-ec-200ug 200ug
EUR 760.8

Recombinant Human Serine/ threonine-protein kinase NIM1 Protein, His-SUMO, E.coli-500ug

QP7811-ec-500ug 500ug
EUR 1272

Recombinant Human Serine/ threonine-protein kinase NIM1 Protein, His-SUMO, E.coli-50ug

QP7811-ec-50ug 50ug
EUR 315.6

NIMA Related Kinase 9 (NEK9) ELISA Kit

abx595418-96tests 96 tests
EUR 764.4

Spare NiMH Battery Pack for PIP9390

PIP9392 EACH
EUR 90

Nimustine (hydrochloride)

HY-13703A 100mg
EUR 680.4

Nimustine hydrochloride

GP5132-1 1
EUR 110.8

NIMA Related Kinase 3 (NEK3) Antibody

abx235653-100ug 100 ug
EUR 577.2

NIMA Related Kinase 9 (NEK9) Antibody

abx235654-100ug 100 ug
EUR 577.2

NIMA Related Kinase 1 (NEK1) Antibody

20-abx212767
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

NIMA Related Kinase 4 (NEK4) Antibody

20-abx212768
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

NIMA Related Kinase 4 (NEK4) Antibody

20-abx212769
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

NIMA Related Kinase 9 (NEK9) Antibody

20-abx212770
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

NIMA Related Kinase 8 (NEK8) Antibody

20-abx214457
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

NIMA Related Kinase 8 (NEK8) Antibody

20-abx214596
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

NIMA Related Kinase 5 (NEK5) Antibody

20-abx210683
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

NIMA Related Kinase 7 (NEK7) Antibody

20-abx141139
  • EUR 427.20
  • EUR 644.40
  • EUR 260.40
  • 100 ul
  • 200 ul
  • 30 ul

NIMA Related Kinase 3 (NEK3) Antibody

20-abx141364
  • EUR 444.00
  • EUR 727.20
  • EUR 360.00
  • 100 ul
  • 200 ul
  • 50 ul

NIMA Related Kinase 8 (NEK8) Antibody

abx117018-100ug 100 ug
EUR 560.4

NIMA Related Kinase 5 (NEK5) Antibody

20-abx325664
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

NIMA Related Kinase 7 (NEK7) Antibody

20-abx325962
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

NIMA Related Kinase 3 (NEK3) Antibody

20-abx321804
  • EUR 526.80
  • EUR 393.60
  • 100 ul
  • 50 ul

NIMA Related Kinase 4 (NEK4) Antibody

20-abx333749
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

NIMA Related Kinase 7 (NEK7) Antibody

20-abx333801
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

NIMA Related Kinase 5 (NEK5) Antibody

20-abx333931
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

NIMA Related Kinase 5 (NEK5) Antibody

abx330693-100ul 100 ul
EUR 510

NIMA Related Kinase 4 (NEK4) Antibody

20-abx326454
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

NIMA Related Kinase 3 (NEK3) Antibody

abx033853-400ul 400 ul
EUR 627.6

NIMA Related Kinase 3 (NEK3) Antibody

abx033853-80l 80 µl
EUR 343.2

NIMA Related Kinase 4 (NEK4) Antibody

abx033854-400ul 400 ul
EUR 627.6

NIMA Related Kinase 4 (NEK4) Antibody

abx033854-80l 80 µl
EUR 343.2

NIMA Related Kinase 7 (NEK7) Antibody

abx033856-400ul 400 ul
EUR 627.6

NIMA Related Kinase 7 (NEK7) Antibody

abx033856-80l 80 µl
EUR 343.2

NIMA Related Kinase 9 (NEK9) Antibody

abx033857-400ul 400 ul
EUR 627.6

NIMA Related Kinase 9 (NEK9) Antibody

abx033857-80l 80 µl
EUR 343.2

NIMA Related Kinase 8 (NEK8) Antibody

abx033172-400ul 400 ul
EUR 627.6

NIMA Related Kinase 8 (NEK8) Antibody

abx033172-80l 80 µl
EUR 343.2

NIMA Related Kinase 8 (NEK8) Antibody

abx122674-100ug 100 ug
EUR 469.2

NIMA Related Kinase 9 (NEK9) Antibody

20-abx328090
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

NIMA Related Kinase 1 (NEK1) Antibody

20-abx334225
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

NIMA Related Kinase 9 (NEK9) Antibody

20-abx338863
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

NIMA Related Kinase 8 (NEK8) Antibody

20-abx321017
  • EUR 526.80
  • EUR 393.60
  • 100 ul
  • 50 ul

NIMA Related Kinase 8 (NEK8) Antibody

20-abx321018
  • EUR 526.80
  • EUR 393.60
  • 100 ul
  • 50 ul

NIMA Related Kinase 5 (NEK5) Antibody

20-abx339915
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

NIMA Related Kinase 7 (NEK7) Antibody

abx432045-200ul 200 ul
EUR 460.8

NIMA Related Kinase 7 (NEK7) Antibody

abx432046-200ul 200 ul
EUR 460.8

NIMA Related Kinase 8 (NEK8) Antibody

20-abx000937
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

NIMA Related Kinase 3 (NEK3) Antibody

20-abx005111
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

NIMA Related Kinase 5 (NEK5) Antibody

20-abx014856
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

NIMA Related Kinase 11 (NEK11) Antibody

abx235650-100ug 100 ug
EUR 577.2

This first try at phenotypic imaging on canine paves the solution to implementing quantitative imaging methodologies that might be transposable to people in a theranostic strategy. Taking under consideration the suggestions of present human radioimmunotherapy scientific trials concentrating on CD22, animal trials are deliberate to analyze protocol enhancements which can be troublesome to think about in people as a result of moral considerations.

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