SPECT-CT Imaging of Dog Spontaneous Diffuse Large B-Cell Lymphoma Targeting CD22 for the Implementation of a Relevant Preclinical Model for Human.
Antibodies directed towards CD22 have been utilized in radioimmunotherapy (RIT) scientific trials to deal with sufferers with diffuse giant B-cell lymphoma (DLBCL) with promising outcomes. However, related preclinical fashions are wanted to facilitate the analysis and optimization of new protocols. Spontaneous DLBCL in canine is a tumor mannequin that will assist speed up the improvement of new methodologies and therapeutic methods for RIT concentrating on CD22.
Seven murine monoclonal antibodies particular for canine CD22 had been produced by the hybridoma technique and characterised. The antibodies‘ affinity and epitopic maps, their internalization functionality and usefulness for prognosis in immunohistochemistry had been decided.
Biodistribution and PET imaging on a mouse xenogeneic mannequin of canine DLBCL was used to decide on the most promising antibody for our functions. PET-CT outcomes confirmed biodistribution examine observations and allowed tumor localization. The chosen antibody, 10C6, was efficiently used on a canine with spontaneous DLBCL for SPECT-CT imaging in the context of illness staging, validating its efficacy for prognosis and the feasibility of future RIT assays.
Nimbolide |
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N476300 | Toronto Research Chemicals | 10mg | EUR 328 |
Description: 25990-37-8 |
Nimbolide |
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T16324-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Nimbolide |
Nimbolide |
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T16324-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Nimbolide |
Nimbolide |
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T16324-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Nimbolide |
Nimbolide |
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T16324-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Nimbolide |
Nimbolide |
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T16324-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Nimbolide |
Nimbolide |
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MBS3840129-10mg | MyBiosource | 10mg | EUR 465 |
Nimbolide |
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MBS3840129-25mg | MyBiosource | 25mg | EUR 810 |
Nimbolide |
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MBS3840129-5mg | MyBiosource | 5mg | EUR 310 |
Nimbolide |
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MBS3840129-5x25mg | MyBiosource | 5x25mg | EUR 3630 |
Nimbolide |
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MBS5764690-1mg | MyBiosource | 1mg | EUR 350 |
Nimbolide |
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MBS5764690-5mg | MyBiosource | 5mg | EUR 510 |
Nimbolide |
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MBS5764690-5x5mg | MyBiosource | 5x5mg | EUR 2155 |
Nimbolide |
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MBS6041837-1mg | MyBiosource | 1(mg | EUR 750 |
Nimbolide |
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MBS6041837-5x1mg | MyBiosource | 5x1mg | EUR 3235 |
Nimbolide |
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HY-116035 | MedChemExpress | 1 mg | EUR 303.04 |
Description: Nimbolide is a triterpene compound that can be isolated from neem (Azadirachta indica), possesses anticancer and antiproliferative activity. Nimbolide induces tumor cell apoptosis by inhibiting NF-κB and CDK4/CDK6 kinase. Nimbolide suppresses the Wnt, PI3K-Akt, MAPK and JAK-STAT signaling pathways[1][2]. |
EZSolution? Nimbolide |
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9655-5 | Biovision | each | EUR 339.6 |
Nimbolide (4a,5a,6a,7a,15b,17a)-7,15:21,23-Diepoxy-6-hydroxy-4,8-dimethyl-1-oxo-18,24-dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic Acid g-lactone Methyl Ester, CCRIS 5723, NSC-309909) |
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MBS6086545-5mg | MyBiosource | 5(mg | EUR 520 |
Nimbolide (4a,5a,6a,7a,15b,17a)-7,15:21,23-Diepoxy-6-hydroxy-4,8-dimethyl-1-oxo-18,24-dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic Acid g-lactone Methyl Ester, CCRIS 5723, NSC-309909) |
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MBS6086545-5x5mg | MyBiosource | 5x5(mg | EUR 2185 |
Nimbolidin B |
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TBZ0660 | ChemNorm | unit | Ask for price |
Nimbolidin C |
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TBZ0661 | ChemNorm | unit | Ask for price |
Nimbolidin D |
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TBZ0662 | ChemNorm | unit | Ask for price |
Nimbolidin E |
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TBZ0663 | ChemNorm | unit | Ask for price |
Nimbosone |
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T33675-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Nimbosone |
Nimbosone |
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T33675-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Nimbosone |
Nimbosone |
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T33675-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Nimbosone |
Nimbosone |
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T33675-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Nimbosone |
Nimbosone |
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T33675-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Nimbosone |
Nimbosone |
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MBS5783217-5mg | MyBiosource | 5(mg | EUR 915 |
Nimbosone |
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MBS5783217-5x5mg | MyBiosource | 5x5(mg | EUR 3970 |
Nimbocinone |
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T25873-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Nimbocinone |
Nimbocinone |
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T25873-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Nimbocinone |
Nimbocinone |
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T25873-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Nimbocinone |
Nimbocinone |
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T25873-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Nimbocinone |
Nimbocinone |
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T25873-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Nimbocinone |
Nimbocinone |
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MBS5775605-5mg | MyBiosource | 5(mg | EUR 915 |
Nimbocinone |
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MBS5775605-5x5mg | MyBiosource | 5x5(mg | EUR 3970 |
Nimbocinone |
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HY-121731 | MedChemExpress | Get quote | Ask for price |
Description: Nimbocinone, isolated from Azadirachta indica, exhibits antidiabetogenic activity[1]. |
Recombinant Macrocallista nimbosa FMRFamide |
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MBS1261626-005mgBaculovirus | MyBiosource | 0.05mg(Baculovirus) | EUR 865 |
Recombinant Macrocallista nimbosa FMRFamide |
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MBS1261626-005mgEColi | MyBiosource | 0.05mg(E-Coli) | EUR 480 |
Recombinant Macrocallista nimbosa FMRFamide |
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MBS1261626-005mgYeast | MyBiosource | 0.05mg(Yeast) | EUR 700 |
Recombinant Macrocallista nimbosa FMRFamide |
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MBS1261626-02mgEColi | MyBiosource | 0.2mg(E-Coli) | EUR 625 |
Recombinant Macrocallista nimbosa FMRFamide |
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MBS1261626-05mgEColi | MyBiosource | 0.5mg(E-Coli) | EUR 685 |
Nimbin |
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N476280 | Toronto Research Chemicals | 1mg | EUR 230 |
Description: 5945-86-8 |
Nimbin |
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TB02317 | ChemNorm | 5mg | EUR 885.6 |
Nimbin |
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TN4659-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Nimbin |
Nimbin |
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TN4659-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Nimbin |
Nimbin |
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TN4659-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Nimbin |
Nimbin |
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TN4659-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Nimbin |
Nimbin |
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TN4659-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Nimbin |
Nimbin |
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MBS6077682-5mg | MyBiosource | 5(mg | EUR 610 |
Nimbin |
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MBS6077682-5x5mg | MyBiosource | 5x5(mg | EUR 2600 |
Nimbin |
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MBS5762850-1mg | MyBiosource | 1mg | EUR 245 |
Nimbin |
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MBS5762850-5x1mg | MyBiosource | 5x1mg | EUR 955 |
Nimbanal |
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N476210 | Toronto Research Chemicals | 1mg | EUR 129 |
Description: 120462-51-3 |
Nimbanal |
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MBS6049221-25mg | MyBiosource | 2.5(mg | EUR 575 |
Nimbanal |
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MBS6049221-5x25mg | MyBiosource | 5x2.5mg | EUR 2440 |
Nimbic Acid |
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MBS6056303-1mg | MyBiosource | 1(mg | EUR 610 |
Nimbic Acid |
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MBS6056303-5x1mg | MyBiosource | 5x1mg | EUR 2600 |
(+)-Nimbidiol |
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N476270 | Toronto Research Chemicals | 25mg | EUR 1800 |
Description: 113332-25-5 |
Nimbidiol |
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T126365-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Nimbidiol |
Nimbidiol |
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T126365-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Nimbidiol |
Nimbidiol |
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T126365-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Nimbidiol |
Nimbidiol |
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T126365-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Nimbidiol |
Nimbidiol |
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T126365-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Nimbidiol |
Nimbidiol |
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MBS5791812-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Nimbinic Acid |
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N476290 | Toronto Research Chemicals | 1mg | EUR 1248 |
Description: 5866-30-8 |
Nimbin acetyl-d3 |
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N476282 | Toronto Research Chemicals | 2.5mg | EUR 1800 |
Desacetyl Nimbin |
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D199000 | Toronto Research Chemicals | 10mg | EUR 409 |
Description: 18609-16-0 |
Desacetyl Nimbin |
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MBS6094527-1mg | MyBiosource | 1(mg | EUR 825 |
Desacetyl Nimbin |
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MBS6094527-5x1mg | MyBiosource | 5x1mg | EUR 3560 |
NIM811 |
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HY-P0025 | MedChemExpress | 10mM/1mL | EUR 4388.4 |
NIM811 |
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T12226-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: NIM811 |
NIM811 |
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T12226-1g | TargetMol Chemicals | 1g | Ask for price |
Description: NIM811 |
NIM811 |
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T12226-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: NIM811 |
NIM811 |
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T12226-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: NIM811 |
NIM811 |
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T12226-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: NIM811 |
NIM811 |
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MBS5753576-5mg | MyBiosource | 5mg | EUR 1170 |
NIM811 |
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MBS5753576-5x5mg | MyBiosource | 5x5mg | EUR 5110 |
Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (AP) |
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MBS6325323-02mL | MyBiosource | 0.2mL | EUR 980 |
Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (AP) |
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MBS6325323-5x02mL | MyBiosource | 5x0.2mL | EUR 4250 |
Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (PE) |
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MBS6325333-02mL | MyBiosource | 0.2mL | EUR 980 |
Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (PE) |
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MBS6325333-5x02mL | MyBiosource | 5x0.2mL | EUR 4250 |
Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) |
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MBS6009790-02mL | MyBiosource | 0.2(mL | EUR 695 |
Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) |
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MBS6009790-5x02mL | MyBiosource | 5x0.2mL | EUR 2975 |
Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (APC) |
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MBS6325324-02mL | MyBiosource | 0.2mL | EUR 980 |
Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (APC) |
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MBS6325324-5x02mL | MyBiosource | 5x0.2mL | EUR 4250 |
Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (FITC) |
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MBS6325326-02mL | MyBiosource | 0.2mL | EUR 980 |
Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (FITC) |
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MBS6325326-5x02mL | MyBiosource | 5x0.2mL | EUR 4250 |
Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (Biotin) |
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MBS6325325-02mL | MyBiosource | 0.2mL | EUR 980 |
Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (Biotin) |
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MBS6325325-5x02mL | MyBiosource | 5x0.2mL | EUR 4250 |
Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (Azide free) (HRP) |
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MBS6325327-02mL | MyBiosource | 0.2mL | EUR 980 |
Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (Azide free) (HRP) |
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MBS6325327-5x02mL | MyBiosource | 5x0.2mL | EUR 4250 |
Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (MaxLight 405) |
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MBS6325328-01mL | MyBiosource | 0.1mL | EUR 980 |
Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (MaxLight 405) |
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MBS6325328-5x01mL | MyBiosource | 5x0.1mL | EUR 4250 |
Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (MaxLight 490) |
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MBS6325329-01mL | MyBiosource | 0.1mL | EUR 980 |
Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (MaxLight 490) |
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MBS6325329-5x01mL | MyBiosource | 5x0.1mL | EUR 4250 |
Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (MaxLight 550) |
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MBS6325330-01mL | MyBiosource | 0.1mL | EUR 980 |
Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (MaxLight 550) |
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MBS6325330-5x01mL | MyBiosource | 5x0.1mL | EUR 4250 |
Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (MaxLight 650) |
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MBS6325331-01mL | MyBiosource | 0.1mL | EUR 980 |
Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (MaxLight 650) |
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MBS6325331-5x01mL | MyBiosource | 5x0.1mL | EUR 4250 |
Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (MaxLight 750) |
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MBS6325332-01mL | MyBiosource | 0.1mL | EUR 980 |
Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (MaxLight 750) |
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MBS6325332-5x01mL | MyBiosource | 5x0.1mL | EUR 4250 |
NIM1 (untagged)-Human serine/threonine-protein kinase NIM1 (NIM1) |
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SC100346 | Origene Technologies GmbH | 10 µg | Ask for price |
NIM1 (GFP-tagged) - Human serine/threonine-protein kinase NIM1 (NIM1) |
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RG207250 | Origene Technologies GmbH | 10 µg | Ask for price |
NIM1 (Myc-DDK-tagged)-Human serine/threonine-protein kinase NIM1 (NIM1) |
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RC207250 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF particles, NIM1K (Myc-DDK tagged) - Human serine/threonine-protein kinase NIM1 (NIM1), 200ul, >10^7 TU/mL |
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RC207250L1V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF particles, NIM1K (mGFP-tagged) - Human serine/threonine-protein kinase NIM1 (NIM1), 200ul, >10^7 TU/mL |
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RC207250L2V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF particles, NIM1K (Myc-DDK tagged) - Human serine/threonine-protein kinase NIM1 (NIM1), 200ul, >10^7 TU/mL |
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RC207250L3V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF particles, NIM1K (mGFP-tagged) - Human serine/threonine-protein kinase NIM1 (NIM1), 200ul, >10^7 TU/mL |
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RC207250L4V | Origene Technologies GmbH | 200 µl | Ask for price |
Human Serine/threonine-protein kinase NIM1 (NIM1) |
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1-CSB-EP810298HU | Cusabio |
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Description: Recombinant Human Serine/threonine-protein kinase NIM1(NIM1) expressed in E.coli |
Mouse Serine/threonine- protein kinase NIM1, Nim1 ELISA KIT |
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ELI-15091m | Nova Lifetech | 96tests | EUR 736 |
Human Serine/threonine- protein kinase NIM1, NIM1 ELISA KIT |
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ELI-16705h | Nova Lifetech | 96tests | EUR 696 |
NIM-7 |
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T33674-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: NIM-7 |
NIM-7 |
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T33674-1g | TargetMol Chemicals | 1g | Ask for price |
Description: NIM-7 |
NIM-7 |
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T33674-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: NIM-7 |
NIM-7 |
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T33674-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: NIM-7 |
NIM-7 |
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T33674-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: NIM-7 |
NIM-7 |
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MBS5783216-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Serine/threonine-Protein Kinase NIM1 (NIM1K) Antibody |
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20-abx110201 | Abbexa |
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This first try at phenotypic imaging on canine paves the solution to implementing quantitative imaging methodologies that might be transposable to people in a theranostic strategy. Taking under consideration the suggestions of present human radioimmunotherapy scientific trials concentrating on CD22, animal trials are deliberate to analyze protocol enhancements which can be troublesome to think about in people as a result of moral considerations.