SPECT-CT Imaging of Dog Spontaneous Diffuse Large B-Cell Lymphoma Targeting CD22 for the Implementation of a Relevant Preclinical Model for Human.

Antibodies directed towards CD22 have been utilized in radioimmunotherapy (RIT) scientific trials to deal with sufferers with diffuse giant B-cell lymphoma (DLBCL) with promising outcomes. However, related preclinical fashions are wanted to facilitate the analysis and optimization of new protocols. Spontaneous DLBCL in canine is a tumor mannequin that will assist speed up the improvement of new methodologies and therapeutic methods for RIT concentrating on CD22.

Seven murine monoclonal antibodies particular for canine CD22 had been produced by the hybridoma technique and characterised. The antibodies‘ affinity and epitopic maps, their internalization functionality and usefulness for prognosis in immunohistochemistry had been decided.

Biodistribution and PET imaging on a mouse xenogeneic mannequin of canine DLBCL was used to decide on the most promising antibody for our functions. PET-CT outcomes confirmed biodistribution examine observations and allowed tumor localization. The chosen antibody, 10C6, was efficiently used on a canine with spontaneous DLBCL for SPECT-CT imaging in the context of illness staging, validating its efficacy for prognosis and the feasibility of future RIT assays.

SPECT-CT Imaging of Dog Spontaneous Diffuse Large B-Cell Lymphoma Targeting CD22 for the Implementation of a Relevant Preclinical Model for Human.
SPECT-CT Imaging of Dog Spontaneous Diffuse Large B-Cell Lymphoma Targeting CD22 for the Implementation of a Relevant Preclinical Model for Human.

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Description: A polyclonal antibody for detection of NIM1 from Human, Mouse. This NIM1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human NIM1 at AA rangle: 320-400

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Description: A polyclonal antibody for detection of NIM1 from Human, Mouse. This NIM1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human NIM1 at AA rangle: 320-400

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Description: Human NIM1K knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

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EUR 255
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Description: Human NIM1K Protein Lysate 20ug

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EUR 370
Description: NIM1 belongs to CAMK Ser/Thr protein kinase family. Unlike to other AMPK-related kinases, NIM1 cannot be phosphorylated and activated by LKB1 . Two somatic mutations (P333S and P411T) were found in lung neuroendocrine carcinoma and lung large cell carcinoma samples .

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1-CSB-PA810298LB01HU
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Description: A polyclonal antibody against NIM1K. Recognizes NIM1K from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

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1-CSB-PA810298LC01HU
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Description: A polyclonal antibody against NIM1K. Recognizes NIM1K from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

NIM1 Rabbit Polyclonal Antibody

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Description: A Rabbit Polyclonal antibody against NIM1 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

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EUR 74
Description: A Rabbit Polyclonal antibody against NIM1 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

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1-CSB-PA810298LD01HU
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EUR 169

Mouse Nim1 Rabbit Polyclonal Antibody

E10G31363 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

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A54359
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This first try at phenotypic imaging on canine paves the solution to implementing quantitative imaging methodologies that might be transposable to people in a theranostic strategy. Taking under consideration the suggestions of present human radioimmunotherapy scientific trials concentrating on CD22, animal trials are deliberate to analyze protocol enhancements which can be troublesome to think about in people as a result of moral considerations.

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