SPECT-CT Imaging of Dog Spontaneous Diffuse Large B-Cell Lymphoma Targeting CD22 for the Implementation of a Relevant Preclinical Model for Human.

Antibodies directed towards CD22 have been utilized in radioimmunotherapy (RIT) scientific trials to deal with sufferers with diffuse giant B-cell lymphoma (DLBCL) with promising outcomes. However, related preclinical fashions are wanted to facilitate the analysis and optimization of new protocols. Spontaneous DLBCL in canine is a tumor mannequin that will assist speed up the improvement of new methodologies and therapeutic methods for RIT concentrating on CD22.

Seven murine monoclonal antibodies particular for canine CD22 had been produced by the hybridoma technique and characterised. The antibodies‘ affinity and epitopic maps, their internalization functionality and usefulness for prognosis in immunohistochemistry had been decided.

Biodistribution and PET imaging on a mouse xenogeneic mannequin of canine DLBCL was used to decide on the most promising antibody for our functions. PET-CT outcomes confirmed biodistribution examine observations and allowed tumor localization. The chosen antibody, 10C6, was efficiently used on a canine with spontaneous DLBCL for SPECT-CT imaging in the context of illness staging, validating its efficacy for prognosis and the feasibility of future RIT assays.

SPECT-CT Imaging of Dog Spontaneous Diffuse Large B-Cell Lymphoma Targeting CD22 for the Implementation of a Relevant Preclinical Model for Human.
SPECT-CT Imaging of Dog Spontaneous Diffuse Large B-Cell Lymphoma Targeting CD22 for the Implementation of a Relevant Preclinical Model for Human.

Nimbolide

N476300 10mg
EUR 328
Description: 25990-37-8

Nimbolide

T16324-10mg 10mg Ask for price
Description: Nimbolide

Nimbolide

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Description: Nimbolide

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Description: Nimbolide

Nimbolide

MBS3840129-10mg 10mg
EUR 465

Nimbolide

MBS3840129-25mg 25mg
EUR 810

Nimbolide

MBS3840129-5mg 5mg
EUR 310

Nimbolide

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EUR 3630

Nimbolide

MBS5764690-1mg 1mg
EUR 350

Nimbolide

MBS5764690-5mg 5mg
EUR 510

Nimbolide

MBS5764690-5x5mg 5x5mg
EUR 2155

Nimbolide

MBS6041837-1mg 1(mg
EUR 750

Nimbolide

MBS6041837-5x1mg 5x1mg
EUR 3235

Nimbolide

HY-116035 1 mg
EUR 303.04
Description: Nimbolide is a triterpene compound that can be isolated from neem (Azadirachta indica), possesses anticancer and antiproliferative activity. Nimbolide induces tumor cell apoptosis by inhibiting NF-κB and CDK4/CDK6 kinase. Nimbolide suppresses the Wnt, PI3K-Akt, MAPK and JAK-STAT signaling pathways[1][2].

EZSolution? Nimbolide

9655-5 each
EUR 339.6

Nimbolide (4a,5a,6a,7a,15b,17a)-7,15:21,23-Diepoxy-6-hydroxy-4,8-dimethyl-1-oxo-18,24-dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic Acid g-lactone Methyl Ester, CCRIS 5723, NSC-309909)

MBS6086545-5mg 5(mg
EUR 520

Nimbolide (4a,5a,6a,7a,15b,17a)-7,15:21,23-Diepoxy-6-hydroxy-4,8-dimethyl-1-oxo-18,24-dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic Acid g-lactone Methyl Ester, CCRIS 5723, NSC-309909)

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EUR 2185

Nimbolidin B

TBZ0660 unit Ask for price

Nimbolidin C

TBZ0661 unit Ask for price

Nimbolidin D

TBZ0662 unit Ask for price

Nimbolidin E

TBZ0663 unit Ask for price

Nimbosone

T33675-10mg 10mg Ask for price
Description: Nimbosone

Nimbosone

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Nimbosone

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Nimbosone

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Nimbosone

MBS5783217-5mg 5(mg
EUR 915

Nimbosone

MBS5783217-5x5mg 5x5(mg
EUR 3970

Nimbocinone

T25873-10mg 10mg Ask for price
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Nimbocinone

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Nimbocinone

T25873-5mg 5mg Ask for price
Description: Nimbocinone

Nimbocinone

MBS5775605-5mg 5(mg
EUR 915

Nimbocinone

MBS5775605-5x5mg 5x5(mg
EUR 3970

Nimbocinone

HY-121731 Get quote Ask for price
Description: Nimbocinone, isolated from Azadirachta indica, exhibits antidiabetogenic activity[1].

Recombinant Macrocallista nimbosa FMRFamide

MBS1261626-005mgBaculovirus 0.05mg(Baculovirus)
EUR 865

Recombinant Macrocallista nimbosa FMRFamide

MBS1261626-005mgEColi 0.05mg(E-Coli)
EUR 480

Recombinant Macrocallista nimbosa FMRFamide

MBS1261626-005mgYeast 0.05mg(Yeast)
EUR 700

Recombinant Macrocallista nimbosa FMRFamide

MBS1261626-02mgEColi 0.2mg(E-Coli)
EUR 625

Recombinant Macrocallista nimbosa FMRFamide

MBS1261626-05mgEColi 0.5mg(E-Coli)
EUR 685

Nimbin

N476280 1mg
EUR 230
Description: 5945-86-8

Nimbin

TB02317 5mg
EUR 885.6

Nimbin

TN4659-10mg 10mg Ask for price
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Nimbin

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Nimbin

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Nimbin

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Nimbin

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Description: Nimbin

Nimbin

MBS6077682-5mg 5(mg
EUR 610

Nimbin

MBS6077682-5x5mg 5x5(mg
EUR 2600

Nimbin

MBS5762850-1mg 1mg
EUR 245

Nimbin

MBS5762850-5x1mg 5x1mg
EUR 955

Nimbanal

N476210 1mg
EUR 129
Description: 120462-51-3

Nimbanal

MBS6049221-25mg 2.5(mg
EUR 575

Nimbanal

MBS6049221-5x25mg 5x2.5mg
EUR 2440

Nimbic Acid

MBS6056303-1mg 1(mg
EUR 610

Nimbic Acid

MBS6056303-5x1mg 5x1mg
EUR 2600

(+)-Nimbidiol

N476270 25mg
EUR 1800
Description: 113332-25-5

Nimbidiol

T126365-10mg 10mg Ask for price
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Nimbidiol

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Nimbidiol

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Nimbidiol

MBS5791812-INQUIRE INQUIRE Ask for price

Nimbinic Acid

N476290 1mg
EUR 1248
Description: 5866-30-8

Nimbin acetyl-d3

N476282 2.5mg
EUR 1800

Desacetyl Nimbin

D199000 10mg
EUR 409
Description: 18609-16-0

Desacetyl Nimbin

MBS6094527-1mg 1(mg
EUR 825

Desacetyl Nimbin

MBS6094527-5x1mg 5x1mg
EUR 3560

NIM811

HY-P0025 10mM/1mL
EUR 4388.4

NIM811

T12226-10mg 10mg Ask for price
Description: NIM811

NIM811

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NIM811

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NIM811

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Description: NIM811

NIM811

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Description: NIM811

NIM811

MBS5753576-5mg 5mg
EUR 1170

NIM811

MBS5753576-5x5mg 5x5mg
EUR 5110

Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (AP)

MBS6325323-02mL 0.2mL
EUR 980

Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (AP)

MBS6325323-5x02mL 5x0.2mL
EUR 4250

Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (PE)

MBS6325333-02mL 0.2mL
EUR 980

Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (PE)

MBS6325333-5x02mL 5x0.2mL
EUR 4250

Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1)

MBS6009790-02mL 0.2(mL
EUR 695

Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1)

MBS6009790-5x02mL 5x0.2mL
EUR 2975

Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (APC)

MBS6325324-02mL 0.2mL
EUR 980

Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (APC)

MBS6325324-5x02mL 5x0.2mL
EUR 4250

Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (FITC)

MBS6325326-02mL 0.2mL
EUR 980

Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (FITC)

MBS6325326-5x02mL 5x0.2mL
EUR 4250

Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (Biotin)

MBS6325325-02mL 0.2mL
EUR 980

Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (Biotin)

MBS6325325-5x02mL 5x0.2mL
EUR 4250

Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (Azide free) (HRP)

MBS6325327-02mL 0.2mL
EUR 980

Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (Azide free) (HRP)

MBS6325327-5x02mL 5x0.2mL
EUR 4250

Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (MaxLight 405)

MBS6325328-01mL 0.1mL
EUR 980

Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (MaxLight 405)

MBS6325328-5x01mL 5x0.1mL
EUR 4250

Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (MaxLight 490)

MBS6325329-01mL 0.1mL
EUR 980

Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (MaxLight 490)

MBS6325329-5x01mL 5x0.1mL
EUR 4250

Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (MaxLight 550)

MBS6325330-01mL 0.1mL
EUR 980

Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (MaxLight 550)

MBS6325330-5x01mL 5x0.1mL
EUR 4250

Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (MaxLight 650)

MBS6325331-01mL 0.1mL
EUR 980

Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (MaxLight 650)

MBS6325331-5x01mL 5x0.1mL
EUR 4250

Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (MaxLight 750)

MBS6325332-01mL 0.1mL
EUR 980

Nim1, CT (Nim1, Serine/threonine-protein kinase NIM1) (MaxLight 750)

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EUR 4250

NIM1 (untagged)-Human serine/threonine-protein kinase NIM1 (NIM1)

SC100346 10 µg Ask for price

NIM1 (GFP-tagged) - Human serine/threonine-protein kinase NIM1 (NIM1)

RG207250 10 µg Ask for price

NIM1 (Myc-DDK-tagged)-Human serine/threonine-protein kinase NIM1 (NIM1)

RC207250 10 µg Ask for price

Lenti ORF particles, NIM1K (Myc-DDK tagged) - Human serine/threonine-protein kinase NIM1 (NIM1), 200ul, >10^7 TU/mL

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Lenti ORF particles, NIM1K (mGFP-tagged) - Human serine/threonine-protein kinase NIM1 (NIM1), 200ul, >10^7 TU/mL

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Human Serine/threonine-protein kinase NIM1 (NIM1)

1-CSB-EP810298HU
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  • 100ug
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Description: Recombinant Human Serine/threonine-protein kinase NIM1(NIM1) expressed in E.coli

Mouse Serine/threonine- protein kinase NIM1, Nim1 ELISA KIT

ELI-15091m 96tests
EUR 736

Human Serine/threonine- protein kinase NIM1, NIM1 ELISA KIT

ELI-16705h 96tests
EUR 696

NIM-7

T33674-10mg 10mg Ask for price
Description: NIM-7

NIM-7

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Description: NIM-7

NIM-7

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Description: NIM-7

NIM-7

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Description: NIM-7

NIM-7

T33674-5mg 5mg Ask for price
Description: NIM-7

NIM-7

MBS5783216-INQUIRE INQUIRE Ask for price

Serine/threonine-Protein Kinase NIM1 (NIM1K) Antibody

20-abx110201
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

This first try at phenotypic imaging on canine paves the solution to implementing quantitative imaging methodologies that might be transposable to people in a theranostic strategy. Taking under consideration the suggestions of present human radioimmunotherapy scientific trials concentrating on CD22, animal trials are deliberate to analyze protocol enhancements which can be troublesome to think about in people as a result of moral considerations.

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