Rational design of peptides for identification of linear epitopes and generation of neutralizing monoclonal antibodies against DKK2 for cancer therapy.
Dickkopf-related protein 2 (DKK2)is a member of the Dickkopf household in Wnt signaling pathway. Recently, we discovered that antibodies against DKK2 might activate pure killer (NK) and CD8+ T cells in tumors and inhibit tumor development. In this paper, we report the rational design of peptides for identification of linear epitopes and generation of neutralizing monoclonal anti-DKK2 antibodies.
To break the immune tolerance, we designed and chemically synthesized six peptides akin to completely different areas of DKK2 as immunogens and discovered 5 of them might generate mouse polyclonal antibodies that may bind to the lively recombinant human DKK2 protein.
Nicotinamide |
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HY-B0150 | MedChemExpress | 10mM/1mL | EUR 135.6 |
Nicotinamide |
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GP9253-100G | Glentham Life Sciences | 100 g | EUR 54 |
Nicotinamide |
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GP9253-1KG | Glentham Life Sciences | 1 kg | EUR 112.8 |
Nicotinamide |
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GP9253-250G | Glentham Life Sciences | 250 g | EUR 64.8 |
Nicotinamide |
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GP9253-25G | Glentham Life Sciences | 25 g | EUR 48 |
Nicotinamide |
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GP9253-500G | Glentham Life Sciences | 500 g | EUR 84 |
Nicotinamide |
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T0934-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Nicotinamide |
Nicotinamide |
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T0934-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Nicotinamide |
Nicotinamide |
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T0934-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Nicotinamide |
Nicotinamide |
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T0934-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Nicotinamide |
Nicotinamide |
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T0934-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Nicotinamide |
Nicotinamide |
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N1651-1000 | ApexBio | 1g | EUR 47 |
Description: PARP-1 inhibitor |
Nicotinamide |
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N1651-5000 | ApexBio | 5g | EUR 62 |
Description: PARP-1 inhibitor |
Nicotinamide |
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41400024-1 | Bio-WORLD | 250 g | EUR 45.48 |
Nicotinamide |
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24317-72 | NACALAI TESQUE | 25G | EUR 12.25 |
Nicotinamide |
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24317-85 | NACALAI TESQUE | 500G | EUR 44.8 |
Nicotinamide |
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TB0209 | ChemNorm | 10X20mg | EUR 328.8 |
Nicotinamide 99% |
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N05200 | Pfaltz & Bauer | 100G | EUR 215.5 |
Nicotinamide, 99% |
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GP9346-1 | Glentham Life Sciences | 1 | EUR 63.3 |
Nicotinamide, 99% |
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GP9346-100 | Glentham Life Sciences | 100 | EUR 16.4 |
Nicotinamide, 99% |
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GP9346-25 | Glentham Life Sciences | 25 | EUR 10.3 |
Nicotinamide, 99% |
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GP9346-250 | Glentham Life Sciences | 250 | EUR 23.8 |
Nicotinamide, 99% |
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GP9346-500 | Glentham Life Sciences | 500 | EUR 39.4 |
Nicotinamide [BSA] |
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DAG3371 | Creative Diagnostics | 1mg | EUR 1014 |
Nicotinamide-d4 |
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464819 | MedKoo Biosciences | 1.0mg | EUR 250 |
Nicotinamide riboside |
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T13795-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Nicotinamide riboside |
Nicotinamide riboside |
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T13795-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Nicotinamide riboside |
Nicotinamide riboside |
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T13795-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Nicotinamide riboside |
Nicotinamide riboside |
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Description: Nicotinamide riboside |
Nicotinamide riboside |
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Description: Nicotinamide riboside |
Nicotinamide ascorbate |
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T33662-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Nicotinamide ascorbate |
Nicotinamide ascorbate |
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T33662-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Nicotinamide ascorbate |
Nicotinamide ascorbate |
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T33662-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Nicotinamide ascorbate |
Nicotinamide ascorbate |
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T33662-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Nicotinamide ascorbate |
Nicotinamide ascorbate |
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T33662-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Nicotinamide ascorbate |
Nicotinamide N-oxide |
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HY-101407 | MedChemExpress | 10mM/1mL | EUR 151.2 |
Nicotinamide N-oxide |
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T0617-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Nicotinamide N-oxide |
Nicotinamide N-oxide |
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T0617-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Nicotinamide N-oxide |
Nicotinamide N-oxide |
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T0617-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Nicotinamide N-oxide |
Nicotinamide N-oxide |
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T0617-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Nicotinamide N-oxide |
Nicotinamide N-oxide |
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T0617-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Nicotinamide N-oxide |
Nicotinamide N-oxide |
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C6736-100 | ApexBio | 100mg | EUR 50 |
Nicotinamide N-oxide |
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C6736-200 | ApexBio | 200mg | EUR 85 |
?-Nicotinamide mononucleotide |
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2733-100 | Biovision | each | EUR 418.8 |
?-Nicotinamide mononucleotide |
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2733-25 | Biovision | each | EUR 196.8 |
?-Nicotinamide mononucleotide |
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2733-250 | Biovision | each | EUR 757.2 |
Nicotinamide Mononucleotide |
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330188 | MedKoo Biosciences | 5.0g | EUR 150 |
Nicotinamide (Vitamin B3) USP |
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N018-100G | TOKU-E | 100 g | EUR 60 |
Nicotinamide (Vitamin B3) USP |
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N018-500G | TOKU-E | 500 g | EUR 147.6 |
Nicotinamide, N-(2-pyridyl)- |
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T33664-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Nicotinamide, N-(2-pyridyl)- |
Nicotinamide, N-(2-pyridyl)- |
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T33664-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Nicotinamide, N-(2-pyridyl)- |
Nicotinamide, N-(2-pyridyl)- |
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T33664-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Nicotinamide, N-(2-pyridyl)- |
Nicotinamide, N-(2-pyridyl)- |
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T33664-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Nicotinamide, N-(2-pyridyl)- |
Nicotinamide, N-(2-pyridyl)- |
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T33664-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Nicotinamide, N-(2-pyridyl)- |
Nicotinamide riboside malate |
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T40060-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Nicotinamide riboside malate |
Nicotinamide riboside malate |
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T40060-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Nicotinamide riboside malate |
Nicotinamide riboside malate |
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T40060-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Nicotinamide riboside malate |
Nicotinamide riboside malate |
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T40060-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Nicotinamide riboside malate |
Nicotinamide riboside malate |
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Description: Nicotinamide riboside malate |
N-(Hydroxymethyl)nicotinamide |
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T7869-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: N-(Hydroxymethyl)nicotinamide |
N-(Hydroxymethyl)nicotinamide |
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Description: N-(Hydroxymethyl)nicotinamide |
N-(Hydroxymethyl)nicotinamide |
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Description: N-(Hydroxymethyl)nicotinamide |
N-(Hydroxymethyl)nicotinamide |
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T7869-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: N-(Hydroxymethyl)nicotinamide |
N-(Hydroxymethyl)nicotinamide |
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T7869-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: N-(Hydroxymethyl)nicotinamide |
Nicotinamide, 99%, Ph. Eur. grade |
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GP9253-1 | Glentham Life Sciences | 1 | EUR 107.2 |
Nicotinamide, 99%, Ph. Eur. grade |
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GP9253-100 | Glentham Life Sciences | 100 | EUR 17.4 |
Nicotinamide, 99%, Ph. Eur. grade |
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GP9253-25 | Glentham Life Sciences | 25 | EUR 10.9 |
Nicotinamide, 99%, Ph. Eur. grade |
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GP9253-250 | Glentham Life Sciences | 250 | EUR 35 |
Nicotinamide, 99%, Ph. Eur. grade |
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GP9253-500 | Glentham Life Sciences | 500 | EUR 61.2 |
Nicotinamide riboside (chloride) |
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HY-123033A | MedChemExpress | 100mg | EUR 129.6 |
Nicotinamide Riboside Triflate |
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T33663-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Nicotinamide Riboside Triflate |
Nicotinamide Riboside Triflate |
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T33663-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Nicotinamide Riboside Triflate |
Nicotinamide Riboside Triflate |
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T33663-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Nicotinamide Riboside Triflate |
Nicotinamide Riboside Triflate |
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T33663-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Nicotinamide Riboside Triflate |
Nicotinamide Riboside Triflate |
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T33663-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Nicotinamide Riboside Triflate |
Nicotinamide riboside chloride |
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T6220-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Nicotinamide riboside chloride |
Nicotinamide riboside chloride |
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T6220-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Nicotinamide riboside chloride |
Nicotinamide riboside chloride |
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T6220-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Nicotinamide riboside chloride |
Nicotinamide riboside chloride |
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T6220-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Nicotinamide riboside chloride |
Nicotinamide riboside chloride |
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T6220-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Nicotinamide riboside chloride |
Nicotinamide Riboside Chloride |
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329479 | MedKoo Biosciences | 1.0g | EUR 150 |
Nicotinamide Riboside Triflate |
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564087 | MedKoo Biosciences | 5.0mg | EUR 550 |
Nicotinamide riboside tartrate |
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T40059-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Nicotinamide riboside tartrate |
Nicotinamide riboside tartrate |
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T40059-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Nicotinamide riboside tartrate |
Nicotinamide riboside tartrate |
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T40059-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Nicotinamide riboside tartrate |
Nicotinamide riboside tartrate |
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T40059-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Nicotinamide riboside tartrate |
Nicotinamide riboside tartrate |
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T40059-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Nicotinamide riboside tartrate |
β-Nicotinamide mononucleotide |
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HY-F0004 | MedChemExpress | 100mg | EUR 374.4 |
β-Nicotinamide mononucleotide |
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T4721-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: β-Nicotinamide mononucleotide |
β-Nicotinamide mononucleotide |
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T4721-1g | TargetMol Chemicals | 1g | Ask for price |
Description: β-Nicotinamide mononucleotide |
β-Nicotinamide mononucleotide |
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T4721-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: β-Nicotinamide mononucleotide |
β-Nicotinamide mononucleotide |
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T4721-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: β-Nicotinamide mononucleotide |
β-Nicotinamide mononucleotide |
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T4721-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: β-Nicotinamide mononucleotide |
Rat Nicotinamide (NAM) ELISA kit |
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E01A15073 | BlueGene | 96T | EUR 700 |
Description: ELISA |
Goat Nicotinamide (NAM) ELISA kit |
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E01A49979 | BlueGene | 96T | EUR 700 |
Description: ELISA |
Mouse Nicotinamide (NAM) ELISA kit |
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E01A23820 | BlueGene | 96T | EUR 700 |
Description: ELISA |
Sheep Nicotinamide (NAM) ELISA kit |
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E01A102273 | BlueGene | 96T | EUR 700 |
Description: ELISA |
Human Nicotinamide (NAM) ELISA kit |
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E01A6326 | BlueGene | 96T | EUR 700 |
Description: ELISA |
Nicotinamide N-methyltransferase |
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AP85746 | SAB | 1mg | EUR 2640 |
Nicotinamide N-methyltransferase |
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AP86059 | SAB | 1mg | EUR 2640 |
Nicotinamide N-methyltransferase |
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AP79064 | SAB | 1mg | EUR 2640 |
Rabbit Nicotinamide (NAM) ELISA kit |
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E01A32544 | BlueGene | 96T | EUR 700 |
Description: ELISA |
Monkey Nicotinamide (NAM) ELISA kit |
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E01A76126 | BlueGene | 96T | EUR 700 |
Description: ELISA |
Bovine Nicotinamide (NAM) ELISA kit |
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E01A84846 | BlueGene | 96T | EUR 700 |
Description: ELISA |
Canine Nicotinamide (NAM) ELISA kit |
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E01A67409 | BlueGene | 96T | EUR 700 |
Description: ELISA |
Chicken Nicotinamide (NAM) ELISA kit |
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E01A93559 | BlueGene | 96T | EUR 700 |
Description: ELISA |
Porcine Nicotinamide (NAM) ELISA kit |
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E01A58697 | BlueGene | 96T | EUR 700 |
Description: ELISA |
Nicotinamide phosphoribosyltransferase |
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AP85818 | SAB | 1mg | EUR 2640 |
Nicotinamide phosphoribosyltransferase |
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AP85986 | SAB | 1mg | EUR 2640 |
Nicotinamide phosphoribosyltransferase |
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AP86446 | SAB | 1mg | EUR 2640 |
Nicotinamide phosphoribosyltransferase |
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AP78602 | SAB | 1mg | EUR 2640 |
Nicotinamide-N-oxide 98%_x000D__x000D_ |
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N05225 | Pfaltz & Bauer | 10G | EUR 279.61 |
Nicotinamide Adenine Dinucleotide (BSA) |
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20-abx165783 | Abbexa |
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Nicotinamide Adenine Dinucleotide (OVA) |
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20-abx165784 | Abbexa |
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Nicotinamide Riboside Chloride (NIAGEN) |
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C7038-100 | ApexBio | 100mg | EUR 50 |
Nicotinamide Riboside Chloride (NIAGEN) |
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C7038-200 | ApexBio | 200mg | EUR 85 |
β-Nicotinamide Adenine Dinucleotide |
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24334-71 | NACALAI TESQUE | 1G | EUR 27.3 |
β-Nicotinamide Adenine Dinucleotide |
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24334-84 | NACALAI TESQUE | 5G | EUR 97.3 |
β-Nicotinamide Adenine Dinucleotide |
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24334-97 | NACALAI TESQUE | 250MG | EUR 16.1 |
β-Nicotinamide Adenine Dinucleotide |
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24338-15 | NACALAI TESQUE | 500MG | EUR 24.5 |
β-Nicotinamide Adenine Dinucleotide |
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24338-31 | NACALAI TESQUE | 1G | EUR 40.6 |
β-Nicotinamide Adenine Dinucleotide |
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24338-44 | NACALAI TESQUE | 5G | EUR 121.8 |
β-Nicotinamide Adenine Dinucleotide |
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24338-57 | NACALAI TESQUE | 250MG | EUR 23.1 |
β-Nicotinamide Adenine Dinucleotide |
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24338-86 | NACALAI TESQUE | 100MG | EUR 9.8 |
Guinea Pig Nicotinamide (NAM) ELISA kit |
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E01A41259 | BlueGene | 96T | EUR 700 |
Description: ELISA |
Nicotinamide N-Methyltransferase Antibody |
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20-abx114105 | Abbexa |
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Nicotinamide, N-(5-(p-aminophenoxy)pentyl)- |
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T33665-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Nicotinamide, N-(5-(p-aminophenoxy)pentyl)- |
Nicotinamide, N-(5-(p-aminophenoxy)pentyl)- |
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T33665-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Nicotinamide, N-(5-(p-aminophenoxy)pentyl)- |
Nicotinamide, N-(5-(p-aminophenoxy)pentyl)- |
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T33665-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Nicotinamide, N-(5-(p-aminophenoxy)pentyl)- |
Nicotinamide, N-(5-(p-aminophenoxy)pentyl)- |
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T33665-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Nicotinamide, N-(5-(p-aminophenoxy)pentyl)- |
Nicotinamide, N-(5-(p-aminophenoxy)pentyl)- |
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T33665-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Nicotinamide, N-(5-(p-aminophenoxy)pentyl)- |
?-Nicotinamide adenine dinucleotide sodium salt |
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9457-1G | Biovision | each | EUR 130.8 |
?-Nicotinamide adenine dinucleotide sodium salt |
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9457-25G | Biovision | each | EUR 914.4 |
?-Nicotinamide adenine dinucleotide sodium salt |
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9457-5G | Biovision | each | EUR 301.2 |
Human Nicotinamide N-methyltransferase (NNMT) |
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1-CSB-EP015906HU | Cusabio |
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Description: Recombinant Human Nicotinamide N-methyltransferase(NNMT) expressed in E.coli |
Nicotinamide N-Methyltransferase (Recombinant) |
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20-abx073298 | Abbexa |
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Nicotinamide Adenine Dinucleotide (NAD) Antibody |
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20-abx130456 | Abbexa |
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Nicotinamide Adenine Dinucleotide (NAD) ELISA Kit |
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20-abx585168 | Abbexa |
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Nicotinamide Adenine Dinucleotide (NAD) ELISA Kit |
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EKU11315-48T | Biomatik Corporation | 48T | EUR 698.53 |
Nicotinamide Adenine Dinucleotide (NAD) ELISA Kit |
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EKU11315-5x96T | Biomatik Corporation | 5x96T | EUR 4740.03 |
Nicotinamide Adenine Dinucleotide (NAD) ELISA Kit |
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EKU11315-96T | Biomatik Corporation | 96T | EUR 997.9 |
Nicotinamide Adenine Dinucleotide (NAD) ELISA Kit |
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EKN52426-48T | Biomatik Corporation | 48T | EUR 434.63 |
Nicotinamide Adenine Dinucleotide (NAD) ELISA Kit |
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EKN52426-5x96T | Biomatik Corporation | 5x96T | EUR 2949.28 |
Nicotinamide Adenine Dinucleotide (NAD) ELISA Kit |
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EKN52426-96T | Biomatik Corporation | 96T | EUR 620.9 |
Neutralizing mousemonoclonalantibodies (5F8 and 1A10) against human DKK2 have been efficiently developed by immunizing the mice with two completely different peptides (34KLNSIKSSL42 and 240KVWKDATYS248) conjugated to Keyhole limpet hemocyanin (KLH). The monoclonalantibodies not solely abolish DKK2’s suppression of Wnt signaling in vitro but additionally inhibits tumor development in vivo. Currently, these two mAbs are present process humanization as immunotherapy candidates and could provide a brand new drug for remedy of human cancers.