Rational design of peptides for identification of linear epitopes and generation of neutralizing monoclonal antibodies against DKK2 for cancer therapy.

Dickkopf-related protein 2 (DKK2)is a member of the Dickkopf household in Wnt signaling pathway. Recently, we discovered that antibodies against DKK2 might activate pure killer (NK) and CD8+ T cells in tumors and inhibit tumor development. In this paper, we report the rational design of peptides for identification of linear epitopes and generation of neutralizing monoclonal anti-DKK2 antibodies.

To break the immune tolerance, we designed and chemically synthesized six peptides akin to completely different areas of DKK2 as immunogens and discovered 5 of them might generate mouse polyclonal antibodies that may bind to the lively recombinant human DKK2 protein.

Nicotinamide

HY-B0150 10mM/1mL
EUR 135.6

Nicotinamide

GP9253-100G 100 g
EUR 54

Nicotinamide

GP9253-1KG 1 kg
EUR 112.8

Nicotinamide

GP9253-250G 250 g
EUR 64.8

Nicotinamide

GP9253-25G 25 g
EUR 48

Nicotinamide

GP9253-500G 500 g
EUR 84

Nicotinamide

T0934-10mg 10mg Ask for price
Description: Nicotinamide

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Description: Nicotinamide

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Description: Nicotinamide

Nicotinamide

N1651-1000 1g
EUR 47
Description: PARP-1 inhibitor

Nicotinamide

N1651-5000 5g
EUR 62
Description: PARP-1 inhibitor

Nicotinamide

41400024-1 250 g
EUR 45.48

Nicotinamide

24317-72 25G
EUR 12.25

Nicotinamide

24317-85 500G
EUR 44.8

Nicotinamide

TB0209 10X20mg
EUR 328.8

Nicotinamide 99%

N05200 100G
EUR 215.5

Nicotinamide, 99%

GP9346-1 1
EUR 63.3

Nicotinamide, 99%

GP9346-100 100
EUR 16.4

Nicotinamide, 99%

GP9346-25 25
EUR 10.3

Nicotinamide, 99%

GP9346-250 250
EUR 23.8

Nicotinamide, 99%

GP9346-500 500
EUR 39.4

Nicotinamide [BSA]

DAG3371 1mg
EUR 1014

Nicotinamide-d4

464819 1.0mg
EUR 250

Nicotinamide riboside

T13795-10mg 10mg Ask for price
Description: Nicotinamide riboside

Nicotinamide riboside

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Description: Nicotinamide riboside

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Nicotinamide N-oxide

HY-101407 10mM/1mL
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Description: Nicotinamide N-oxide

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Nicotinamide N-oxide

C6736-100 100mg
EUR 50

Nicotinamide N-oxide

C6736-200 200mg
EUR 85

?-Nicotinamide mononucleotide

2733-100 each
EUR 418.8

?-Nicotinamide mononucleotide

2733-25 each
EUR 196.8

?-Nicotinamide mononucleotide

2733-250 each
EUR 757.2

Nicotinamide Mononucleotide

330188 5.0g
EUR 150

Nicotinamide (Vitamin B3) USP

N018-100G 100 g
EUR 60

Nicotinamide (Vitamin B3) USP

N018-500G 500 g
EUR 147.6

Nicotinamide, N-(2-pyridyl)-

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Description: Nicotinamide, N-(2-pyridyl)-

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Description: Nicotinamide, N-(2-pyridyl)-

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Description: Nicotinamide, N-(2-pyridyl)-

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Description: Nicotinamide, N-(2-pyridyl)-

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Description: Nicotinamide riboside malate

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Description: Nicotinamide riboside malate

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Description: Nicotinamide riboside malate

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Description: Nicotinamide riboside malate

N-(Hydroxymethyl)nicotinamide

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Description: N-(Hydroxymethyl)nicotinamide

N-(Hydroxymethyl)nicotinamide

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Description: N-(Hydroxymethyl)nicotinamide

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Description: N-(Hydroxymethyl)nicotinamide

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Description: N-(Hydroxymethyl)nicotinamide

Nicotinamide, 99%, Ph. Eur. grade

GP9253-1 1
EUR 107.2

Nicotinamide, 99%, Ph. Eur. grade

GP9253-100 100
EUR 17.4

Nicotinamide, 99%, Ph. Eur. grade

GP9253-25 25
EUR 10.9

Nicotinamide, 99%, Ph. Eur. grade

GP9253-250 250
EUR 35

Nicotinamide, 99%, Ph. Eur. grade

GP9253-500 500
EUR 61.2

Nicotinamide riboside (chloride)

HY-123033A 100mg
EUR 129.6

Nicotinamide Riboside Triflate

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Description: Nicotinamide Riboside Triflate

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Description: Nicotinamide Riboside Triflate

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Description: Nicotinamide Riboside Triflate

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Description: Nicotinamide Riboside Triflate

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Nicotinamide riboside chloride

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Description: Nicotinamide riboside chloride

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Description: Nicotinamide riboside chloride

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Description: Nicotinamide riboside chloride

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Description: Nicotinamide riboside chloride

Nicotinamide Riboside Chloride

329479 1.0g
EUR 150

Nicotinamide Riboside Triflate

564087 5.0mg
EUR 550

Nicotinamide riboside tartrate

T40059-10mg 10mg Ask for price
Description: Nicotinamide riboside tartrate

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Description: Nicotinamide riboside tartrate

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Description: Nicotinamide riboside tartrate

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Description: Nicotinamide riboside tartrate

β-Nicotinamide mononucleotide

HY-F0004 100mg
EUR 374.4

β-Nicotinamide mononucleotide

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Description: β-Nicotinamide mononucleotide

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Description: β-Nicotinamide mononucleotide

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Description: β-Nicotinamide mononucleotide

Rat Nicotinamide (NAM) ELISA kit

E01A15073 96T
EUR 700
Description: ELISA

Goat Nicotinamide (NAM) ELISA kit

E01A49979 96T
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Description: ELISA

Mouse Nicotinamide (NAM) ELISA kit

E01A23820 96T
EUR 700
Description: ELISA

Sheep Nicotinamide (NAM) ELISA kit

E01A102273 96T
EUR 700
Description: ELISA

Human Nicotinamide (NAM) ELISA kit

E01A6326 96T
EUR 700
Description: ELISA

Nicotinamide N-methyltransferase

AP85746 1mg
EUR 2640

Nicotinamide N-methyltransferase

AP86059 1mg
EUR 2640

Nicotinamide N-methyltransferase

AP79064 1mg
EUR 2640

Rabbit Nicotinamide (NAM) ELISA kit

E01A32544 96T
EUR 700
Description: ELISA

Monkey Nicotinamide (NAM) ELISA kit

E01A76126 96T
EUR 700
Description: ELISA

Bovine Nicotinamide (NAM) ELISA kit

E01A84846 96T
EUR 700
Description: ELISA

Canine Nicotinamide (NAM) ELISA kit

E01A67409 96T
EUR 700
Description: ELISA

Chicken Nicotinamide (NAM) ELISA kit

E01A93559 96T
EUR 700
Description: ELISA

Porcine Nicotinamide (NAM) ELISA kit

E01A58697 96T
EUR 700
Description: ELISA

Nicotinamide phosphoribosyltransferase

AP85818 1mg
EUR 2640

Nicotinamide phosphoribosyltransferase

AP85986 1mg
EUR 2640

Nicotinamide phosphoribosyltransferase

AP86446 1mg
EUR 2640

Nicotinamide phosphoribosyltransferase

AP78602 1mg
EUR 2640

Nicotinamide-N-oxide 98%_x000D__x000D_

N05225 10G
EUR 279.61

Nicotinamide Adenine Dinucleotide (BSA)

20-abx165783
  • EUR 760.80
  • EUR 326.40
  • EUR 2281.20
  • EUR 895.20
  • EUR 543.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Nicotinamide Adenine Dinucleotide (OVA)

20-abx165784
  • EUR 760.80
  • EUR 326.40
  • EUR 2281.20
  • EUR 895.20
  • EUR 543.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Nicotinamide Riboside Chloride (NIAGEN)

C7038-100 100mg
EUR 50

Nicotinamide Riboside Chloride (NIAGEN)

C7038-200 200mg
EUR 85

β-Nicotinamide Adenine Dinucleotide

24334-71 1G
EUR 27.3

β-Nicotinamide Adenine Dinucleotide

24334-84 5G
EUR 97.3

β-Nicotinamide Adenine Dinucleotide

24334-97 250MG
EUR 16.1

β-Nicotinamide Adenine Dinucleotide

24338-15 500MG
EUR 24.5

β-Nicotinamide Adenine Dinucleotide

24338-31 1G
EUR 40.6

β-Nicotinamide Adenine Dinucleotide

24338-44 5G
EUR 121.8

β-Nicotinamide Adenine Dinucleotide

24338-57 250MG
EUR 23.1

β-Nicotinamide Adenine Dinucleotide

24338-86 100MG
EUR 9.8

Guinea Pig Nicotinamide (NAM) ELISA kit

E01A41259 96T
EUR 700
Description: ELISA

Nicotinamide N-Methyltransferase Antibody

20-abx114105
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Nicotinamide, N-(5-(p-aminophenoxy)pentyl)-

T33665-10mg 10mg Ask for price
Description: Nicotinamide, N-(5-(p-aminophenoxy)pentyl)-

Nicotinamide, N-(5-(p-aminophenoxy)pentyl)-

T33665-1g 1g Ask for price
Description: Nicotinamide, N-(5-(p-aminophenoxy)pentyl)-

Nicotinamide, N-(5-(p-aminophenoxy)pentyl)-

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Description: Nicotinamide, N-(5-(p-aminophenoxy)pentyl)-

Nicotinamide, N-(5-(p-aminophenoxy)pentyl)-

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Description: Nicotinamide, N-(5-(p-aminophenoxy)pentyl)-

Nicotinamide, N-(5-(p-aminophenoxy)pentyl)-

T33665-5mg 5mg Ask for price
Description: Nicotinamide, N-(5-(p-aminophenoxy)pentyl)-

?-Nicotinamide adenine dinucleotide sodium salt

9457-1G each
EUR 130.8

?-Nicotinamide adenine dinucleotide sodium salt

9457-25G each
EUR 914.4

?-Nicotinamide adenine dinucleotide sodium salt

9457-5G each
EUR 301.2

Human Nicotinamide N-methyltransferase (NNMT)

1-CSB-EP015906HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Nicotinamide N-methyltransferase(NNMT) expressed in E.coli

Nicotinamide N-Methyltransferase (Recombinant)

20-abx073298
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 25 ug
  • 5 ug

Nicotinamide Adenine Dinucleotide (NAD) Antibody

20-abx130456
  • EUR 510.00
  • EUR 159.60
  • EUR 1412.40
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Nicotinamide Adenine Dinucleotide (NAD) ELISA Kit

20-abx585168
  • EUR 9567.60
  • EUR 5095.20
  • EUR 1177.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Nicotinamide Adenine Dinucleotide (NAD) ELISA Kit

EKU11315-48T 48T
EUR 698.53

Nicotinamide Adenine Dinucleotide (NAD) ELISA Kit

EKU11315-5x96T 5x96T
EUR 4740.03

Nicotinamide Adenine Dinucleotide (NAD) ELISA Kit

EKU11315-96T 96T
EUR 997.9

Nicotinamide Adenine Dinucleotide (NAD) ELISA Kit

EKN52426-48T 48T
EUR 434.63

Nicotinamide Adenine Dinucleotide (NAD) ELISA Kit

EKN52426-5x96T 5x96T
EUR 2949.28

Nicotinamide Adenine Dinucleotide (NAD) ELISA Kit

EKN52426-96T 96T
EUR 620.9

Neutralizing mousemonoclonalantibodies (5F8 and 1A10) against human DKK2 have been efficiently developed by immunizing the mice with two completely different peptides (34KLNSIKSSL42 and 240KVWKDATYS248) conjugated to Keyhole limpet hemocyanin (KLH). The monoclonalantibodies not solely abolish DKK2’s suppression of Wnt signaling in vitro but additionally inhibits tumor development in vivo. Currently, these two mAbs are present process humanization as immunotherapy candidates and could provide a brand new drug for remedy of human cancers.

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