Dickkopf-related protein 2 (DKK2)is a member of the Dickkopf household in Wnt signaling pathway. Recently, we discovered that antibodies against DKK2 might activate pure killer (NK) and CD8+ T cells in tumors and inhibit tumor development. In this paper, we report the rational design of peptides for identification of linear epitopes and generation of neutralizing monoclonal anti-DKK2 antibodies .
To break the immune tolerance, we designed and chemically synthesized six peptides akin to completely different areas of DKK2 as immunogens and discovered 5 of them might generate mouse polyclonal antibodies that may bind to the lively recombinant human DKK2 protein.
Nicotinamide
N1651-5.1
ApexBio
10 mM (in 1mL DMSO)
EUR 142
Description: IC50: N/ANicotinamide is an inhibitor of poly(ADP-ribose) polymerase (PARP-1) enzymes. Poly(ADP-ribose) polymerase-1 (PARP-1) is found as a DNA repair enzyme.
Nicotinamide
N1651-50
ApexBio
50 mg
EUR 131
Description: IC50: N/ANicotinamide is an inhibitor of poly(ADP-ribose) polymerase (PARP-1) enzymes. Poly(ADP-ribose) polymerase-1 (PARP-1) is found as a DNA repair enzyme.
Nicotinamide
TB0209
ChemNorm
10X20mg
EUR 274
?-Nicotinamide mononucleotide
2733-100
Biovision
EUR 349
?-Nicotinamide mononucleotide
2733-25
Biovision
EUR 164
?-Nicotinamide mononucleotide
2733-250
Biovision
EUR 631
Nicotinamide riboside (chloride)
HY-123033A
MedChemExpress
100mg
EUR 108
Beta-Nicotinamide Mononucleotide
abx188614-100g
Abbexa
100 g
EUR 1469
beta-Nicotinamide mononucleotide
B7878-100
ApexBio
100 mg
EUR 108
beta-Nicotinamide mononucleotide
B7878-500
ApexBio
500 mg
EUR 166
Beta-Nicotinamide Mononucleotide
TBW01655
ChemNorm
20mg
Ask for price
Nicotinamide (Vitamin B3) USP
N018-100G
TOKU-E
100 g
EUR 50
Nicotinamide (Vitamin B3) USP
N018-500G
TOKU-E
500 g
EUR 123
Nicotinamide N-Methyltransferase Antibody
20-abx114105
Abbexa
Nicotinamide Nucleotide Transhydrogenase Antibody
20-abx114107
Abbexa
Nicotinamide N-Methyltransferase (Recombinant)
20-abx073298
Abbexa
EUR 3418.00
EUR 328.00
EUR 230.00
Nicotinamide Adenine Dinucleotide (BSA)
20-abx165783
Abbexa
EUR 634.00
EUR 272.00
EUR 1901.00
EUR 746.00
EUR 453.00
100 ug
10 ug
1 mg
200 ug
50 ug
Nicotinamide Adenine Dinucleotide (OVA)
20-abx165784
Abbexa
EUR 634.00
EUR 272.00
EUR 1901.00
EUR 746.00
EUR 453.00
100 ug
10 ug
1 mg
200 ug
50 ug
beta-Nicotinamide adenine dinucleotide
B7877-100
ApexBio
100 mg
EUR 108
beta-Nicotinamide adenine dinucleotide
B7877-500
ApexBio
500 mg
EUR 166
Nicotinamide Adenine Dinucleotide (NAD) Antibody
20-abx130456
Abbexa
EUR 425.00
EUR 133.00
EUR 1177.00
EUR 578.00
EUR 328.00
100 ug
10 ug
1 mg
200 ug
50 ug
Nicotinamide N-Methyltransferase (NNMT) Antibody
abx122668-100ug
Abbexa
100 ug
EUR 391
Nicotinamide Nucleotide Adenylyltransferase 1 Antibody
20-abx137248
Abbexa
EUR 704.00
EUR 328.00
EUR 230.00
Nicotinamide-N-Methyltransferase (NNMT) Antibody
20-abx103358
Abbexa
EUR 425.00
EUR 133.00
EUR 1205.00
EUR 578.00
EUR 328.00
100 ug
10 ug
1 mg
200 ug
50 ug
Nicotinamide-N-Methyltransferase (NNMT) Antibody
20-abx103359
Abbexa
EUR 439.00
EUR 133.00
EUR 1233.00
EUR 592.00
EUR 328.00
100 ug
10 ug
1 mg
200 ug
50 ug
Nicotinamide-N-Methyltransferase (NNMT) Antibody
20-abx103360
Abbexa
EUR 439.00
EUR 133.00
EUR 1233.00
EUR 592.00
EUR 328.00
100 ug
10 ug
1 mg
200 ug
50 ug
Nicotinamide Nucleotide Adenylyltransferase 1 (Recombinant)
20-abx073291
Abbexa
EUR 3418.00
EUR 328.00
EUR 230.00
Nicotinamide Nucleotide Adenylyltransferase 2 (Recombinant)
20-abx073965
Abbexa
EUR 1609.00
EUR 328.00
EUR 230.00
Nicotinamide Nucleotide Transhydrogenase (NNT) Antibody
20-abx007786
Abbexa
EUR 300.00
EUR 439.00
EUR 189.00
Nicotinamide Nucleotide Transhydrogenase (NNT) Antibody
20-abx003424
Abbexa
EUR 411.00
EUR 592.00
EUR 182.00
EUR 314.00
100 ul
200 ul
20 ul
50 ul
Nicotinamide N-Methyltransferase (NNMT) Antibody
20-abx005116
Abbexa
EUR 411.00
EUR 592.00
EUR 182.00
EUR 314.00
100 ul
200 ul
20 ul
50 ul
Nicotinamide N-Methyltransferase (NNMT) Antibody
abx025652-400ul
Abbexa
400 ul
EUR 523
Nicotinamide N-Methyltransferase (NNMT) Antibody
abx025652-80l
Abbexa
80 µl
EUR 286
Nicotinamide N-Methyltransferase (NNMT) Antibody
abx027598-400ul
Abbexa
400 ul
EUR 523
Nicotinamide N-Methyltransferase (NNMT) Antibody
abx027598-80l
Abbexa
80 µl
EUR 286
Recombinant Human Nicotinamide N-Methyltransferase
7-03229
CHI Scientific
5µg
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Recombinant Human Nicotinamide N-Methyltransferase
7-03230
CHI Scientific
25µg
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Recombinant Human Nicotinamide N-Methyltransferase
7-03231
CHI Scientific
1mg
Ask for price
Nicotinamide N-Methyltransferase (NNMT) Antibody
abx431457-200ul
Abbexa
200 ul
EUR 384
Nicotinamide N-Methyltransferase (NNMT) Antibody
abx433044-200ul
Abbexa
200 ul
EUR 384
Nicotinamide N-Methyltransferase (NNMT) Antibody
20-abx301014
Abbexa
EUR 411.00
EUR 1845.00
EUR 599.00
EUR 182.00
EUR 300.00
100 ug
1 mg
200 ug
20 ug
50 ug
Nicotinamide N-Methyltransferase (NNMT) Antibody
20-abx321820
Abbexa
N-Benzyl-5-bromo-nicotinamide
20-abx186522
Abbexa
EUR 217.00
EUR 648.00
EUR 328.00
Nicotinamide Nucleotide Transhydrogenase (NNT) Antibody
20-abx217198
Abbexa
Nicotinamide Nucleotide Transhydrogenase (NNT) Antibody
abx146315-100ug
Abbexa
100 ug
EUR 391
Nicotinamide N-Methyltransferase (NNMT) Antibody
abx235773-100ug
Abbexa
100 ug
EUR 509
Nicotinamide Nucleotide Transhydrogenase (NNT) Antibody
abx235775-100ug
Abbexa
100 ug
EUR 481
Nicotinamide N-Methyltransferase (NNMT) Antibody
20-abx141366
Abbexa
EUR 370.00
EUR 606.00
EUR 300.00
Nicotinamide-N-Methyltransferase (NNMT) Antibody
20-abx173825
Abbexa
Human Nicotinamide N-methyltransferase (NNMT)
1-CSB-EP015906HU
Cusabio
EUR 380.00
EUR 214.00
EUR 1309.00
EUR 560.00
EUR 873.00
EUR 262.00
100ug
10ug
1MG
200ug
500ug
50ug
Description: Recombinant Human Nicotinamide N-methyltransferase(NNMT) expressed in E.coli
Recombinant Nicotinamide-N-Methyltransferase (NNMT)
4-RPH530Hu01
Cloud-Clone
EUR 490.66
EUR 234.00
EUR 1564.96
EUR 588.32
EUR 1076.64
EUR 391.00
EUR 3762.40
100 ug
10ug
1 mg
200 ug
500 ug
50ug
5 mg
Description: Recombinant Human Nicotinamide-N-Methyltransferase expressed in: E.coli
Recombinant Nicotinamide-N-Methyltransferase (NNMT)
4-RPH530Mu01
Cloud-Clone
EUR 476.32
EUR 230.00
EUR 1511.20
EUR 570.40
EUR 1040.80
EUR 382.00
EUR 3628.00
100 ug
10ug
1 mg
200 ug
500 ug
50ug
5 mg
Description: Recombinant Mouse Nicotinamide-N-Methyltransferase expressed in: E.coli
Recombinant Nicotinamide-N-Methyltransferase (NNMT)
4-RPH530Mu02
Cloud-Clone
EUR 476.32
EUR 230.00
EUR 1511.20
EUR 570.40
EUR 1040.80
EUR 382.00
EUR 3628.00
100 ug
10ug
1 mg
200 ug
500 ug
50ug
5 mg
Description: Recombinant Mouse Nicotinamide-N-Methyltransferase expressed in: E.coli
?-Nicotinamide adenine dinucleotide sodium salt
9457-1G
Biovision
EUR 109
?-Nicotinamide adenine dinucleotide sodium salt
9457-25G
Biovision
EUR 762
?-Nicotinamide adenine dinucleotide sodium salt
9457-5G
Biovision
EUR 251
Nicotinamide Adenine Dinucleotide (NAD) ELISA Kit
20-abx585168
Abbexa
EUR 7973.00
EUR 4246.00
EUR 981.00
10 × 96 tests
5 × 96 tests
96 tests
NNMTMouse Nicotinamide N-Methyltransferase MouseRecombinant Protein
PROTO55239
BosterBio
Regular: 10ug
EUR 317
Description: NNMT Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 288 amino acids (1-264a.a) and having a molecular mass of 32.1kDa.;NNMT is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Pig NAMPT/ Nicotinamide phosphoribosyltransferase ELISA Kit
E0138Pi
Sunlong
1 Kit
EUR 717
Mouse Nampt/ Nicotinamide phosphoribosyltransferase ELISA Kit
E1008Mo
Sunlong
1 Kit
EUR 571
Rat Nampt/ Nicotinamide phosphoribosyltransferase ELISA Kit
E0659Ra
Sunlong
1 Kit
EUR 571
Human NAMPT/ Nicotinamide phosphoribosyltransferase ELISA Kit
E2812Hu
Sunlong
1 Kit
EUR 563
Nicotinamide Nucleotide Adenylyltransferase 3 (NMNAT3) Antibody
abx122119-100ug
Abbexa
100 ug
EUR 391
Nicotinamide Nucleotide Adenylyltransferase 1 (NMNAT1) Antibody
abx122669-100ug
Abbexa
100 ug
EUR 391
Nicotinamide Nucleotide Adenylyltransferase 1 (NMNAT1) Antibody
20-abx114106
Abbexa
Human Nicotinamide-N-Methyltransferase (NNMT) Protein
20-abx068292
Abbexa
EUR 690.00
EUR 286.00
EUR 2110.00
EUR 815.00
EUR 495.00
100 ug
10 ug
1 mg
200 ug
50 ug
Mouse Nicotinamide-N-Methyltransferase (NNMT) Protein
20-abx068293
Abbexa
EUR 662.00
EUR 272.00
EUR 2040.00
EUR 787.00
EUR 481.00
100 ug
10 ug
1 mg
200 ug
50 ug
Mouse Nicotinamide-N-Methyltransferase (NNMT) Protein
20-abx068294
Abbexa
EUR 662.00
EUR 272.00
EUR 2040.00
EUR 787.00
EUR 481.00
100 ug
10 ug
1 mg
200 ug
50 ug
Nicotinamide Riboside Kinase 1 (C9orf95) Antibody
abx034456-400ul
Abbexa
400 ul
EUR 523
Nicotinamide Riboside Kinase 1 (C9orf95) Antibody
abx034456-80l
Abbexa
80 µl
EUR 286
Nicotinamide Nucleotide Adenylyltransferase 1 (NMNAT1) Antibody
20-abx003756
Abbexa
Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Antibody
abx018035-100ug
Abbexa
100 ug
EUR 342
Recombinant Human Nicotinamide Nucleotide Adenylyltransferase 1
7-03223
CHI Scientific
5µg
Ask for price
Recombinant Human Nicotinamide Nucleotide Adenylyltransferase 1
7-03224
CHI Scientific
20µg
Ask for price
Recombinant Human Nicotinamide Nucleotide Adenylyltransferase 1
7-03225
CHI Scientific
1mg
Ask for price
Nicotinamide Nucleotide Adenylyltransferase 3 (Nmnat3) Antibody
abx432172-200ul
Abbexa
200 ul
EUR 384
Nicotinamide Nucleotide Adenylyltransferase 3 (NMNAT3) Antibody
abx433042-200ul
Abbexa
200 ul
EUR 286
Nicotinamide Nucleotide Adenylyltransferase 3 (NMNAT3) Antibody
abx433043-200ul
Abbexa
200 ul
EUR 384
Nicotinamide-N-Methyltransferase (NNMT) Antibody (FITC)
20-abx274230
Abbexa
EUR 495.00
EUR 258.00
EUR 1455.00
EUR 676.00
EUR 398.00
100 ug
10 ug
1 mg
200 ug
50 ug
Nicotinamide Nucleotide Adenylyltransferase 3 (NMNAT3) Antibody
20-abx317916
Abbexa
EUR 411.00
EUR 1845.00
EUR 599.00
EUR 182.00
EUR 300.00
100 ug
1 mg
200 ug
20 ug
50 ug
Nicotinamide Nucleotide Adenylyltransferase 1 (NMNAT1) Antibody
20-abx320762
Abbexa
Nicotinamide Nucleotide Adenylyltransferase 1 (NMNAT1) Antibody
20-abx320763
Abbexa
Nicotinamide N-Methyltransferase (NNMT) Antibody (HRP)
20-abx314889
Abbexa
EUR 411.00
EUR 1845.00
EUR 599.00
EUR 182.00
EUR 300.00
100 ug
1 mg
200 ug
20 ug
50 ug
Nicotinamide N-Methyltransferase (NNMT) Antibody (FITC)
20-abx314890
Abbexa
EUR 411.00
EUR 1845.00
EUR 599.00
EUR 182.00
EUR 300.00
100 ug
1 mg
200 ug
20 ug
50 ug
Neutralizing mousemonoclonalantibodies (5F8 and 1A10) against human DKK2 have been efficiently developed by immunizing the mice with two completely different peptides (34 KLNSIKSSL42 and 240 KVWKDATYS248 ) conjugated to Keyhole limpet hemocyanin (KLH). The monoclonalantibodies not solely abolish DKK2’s suppression of Wnt signaling in vitro but additionally inhibits tumor development in vivo. Currently, these two mAbs are present process humanization as immunotherapy candidates and could provide a brand new drug for remedy of human cancers.